1-Pyridine-4-yl-piperidine-4-carboxylic acid

Basic Information

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CAS Number

93913-86-1

Molecular Formula

C11H14N2O2

Molecular Weight

206.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

407.9°Cat760mmHg

Density

1.233

Flash Point

200.5°C

Refractive Index

1.575

SMILES

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C1CN(CCC1C(=O)O)C2=CC=NC=C2

InChI

InChI=1S/C11H14N2O2/c14-11(15)9-3-7-13(8-4-9)10-1-5-12-6-2-10/h1-2,5-6,9H,3-4,7-8H2,(H,14,15)

InChIKey

UISWRUUBFFHGLE-UHFFFAOYSA-N

LogP

1.3826

Topological Polar Surface Area

53.43000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

219

Synonyms & References

English

1-Pyridine-4-yl-piperidine-4-carboxylic acid
1-(4-pyridinyl)-4-Piperidinecarboxylic acid
1-Pyridin-4-yl-piperidine-4-carboxylic acid
1-pyridin-4-ylpiperidine-4-carboxylic acid
4-Piperidinecarboxylicacid, 1-(4-pyridinyl)-
1-(pyridin-4-yl)piperidine-4-carboxylic acid
1-(pyridin-4-yl)-piperidine-4-carboxylic acid
4-Piperidinecarboxylic acid, 1-(4-pyridinyl)-
1-(4-pyridyl)piperidine-4-carboxylic acid
3,4,5,6-tetrahydro-2h-[1,4']bipyridinyl-4-carboxylic acid
C2142
N-(4-pyridyl)isonipecotic acid
N-P
1-(4-Pyridinyl)-4-piperidinecarboxylic acid (ACI)
1-(4-Pyridinyl)piperidine-4-carboxylic acid
1-(4-Pyridyl)-4-piperidinecarboxylic acid
1-Pyridine-4-yl-piperidine-4-carboxylicacid
3,4,5,6-Tetrahydro-2H-[1,4′]bipyridinyl-4-carboxylic acid
N-Pyridin-4-ylisonipecotic acid
MFCD08235220
AKOS000177996
SB40099
1-(4-pyridinyl)piperidin-4-ylcarboxylic acid
J-505118
1-pyridin-4-ylpiperidine-4-carboxylic Acid
1-(pyrid-4-yl)-4-(carboxy)piperidine
1-(4-pyridinyl)-4-piperidinecarboxylic acid
CS-0110302
1-pyridine-4-yl-piperidine-4-carboxylic acid
UISWRUUBFFHGLE-UHFFFAOYSA-N
1-Pyridin-4-ylpiperidin-4-carboxylic acid

MDL Number

MFCD08235220

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1-Pyridine-4-yl-piperidine-4-carboxylic acid (CAS: 93913-86-1)?

1-Pyridine-4-yl-piperidine-4-carboxylic acid is a solid with a crystalline form. The molecular weight is approximately 254.26 g/mol. It has low solubility in water but good solubility in organic solvents like DMSO and DMF. It is moderately reactive, especially towards nucleophiles. It is used in various chemical reactions and can form stable salts and esters.

How is 1-Pyridine-4-yl-piperidine-4-carboxylic acid (CAS: 93913-86-1) typically synthesized?

1-Pyridine-4-yl-piperidine-4-carboxylic acid is synthesized via a Michael addition followed by a Williamson ether synthesis. Commonly, pyridine-4-carbaldehyde reacts with piperidine-4-carboxylic acid in the presence of a base like sodium hydride. The yield is around 75-80%.

What industries use 1-Pyridine-4-yl-piperidine-4-carboxylic acid (CAS: 93913-86-1)?

1-Pyridine-4-yl-piperidine-4-carboxylic acid is used in the pharmaceutical industry for drug development due to its structural complexity and potential biological activities. It is also applicable in polymer synthesis and as a functional group in organic electronics and sensors.

What precautions should be taken when handling 1-Pyridine-4-yl-piperidine-4-carboxylic acid (CAS: 93913-86-1)?

When handling 1-Pyridine-4-yl-piperidine-4-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Use a fume hood during synthesis and storage. In case of a spill, contain it and dispose of it according to the Material Safety Data Sheet (SDS).