1-Pyridine-4-yl-piperidine-4-carboxylic acid(CAS: 93913-86-1)

1-Pyridine-4-yl-piperidine-4-carboxylic acid is a solid with a crystalline form. The molecular weight is approximately 254.26 g/mol. It has low solubility in water but good solubility in organic solvents like DMSO and DMF. It is moderately reactive, especially towards nucleophiles. It is used in various chemical reactions and can form stable salts and esters.

1-Pyridine-4-yl-piperidine-4-carboxylic acid is synthesized via a Michael addition followed by a Williamson ether synthesis. Commonly, pyridine-4-carbaldehyde reacts with piperidine-4-carboxylic acid in the presence of a base like sodium hydride. The yield is around 75-80%.

1-Pyridine-4-yl-piperidine-4-carboxylic acid is used in the pharmaceutical industry for drug development due to its structural complexity and potential biological activities. It is also applicable in polymer synthesis and as a functional group in organic electronics and sensors.

When handling 1-Pyridine-4-yl-piperidine-4-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Use a fume hood during synthesis and storage. In case of a spill, contain it and dispose of it according to the Material Safety Data Sheet (SDS).