Ethenzamide | CAS No. 938-73-8

Q: What are the physical and chemical properties of Ethenzamide (CAS: 938-73-8)?

Ethenzamide is a colorless or white crystalline solid with a molecular weight of approximately 132.13 g/mol. It has a melting point of 78-80°C and is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong bases. It is used in various applications due to its reactivity and solubility properties.

Q: How is Ethenzamide (CAS: 938-73-8) typically synthesized?

Ethenzamide is typically synthesized through the amidation of ethyl acetoacetate with ammonia or an amine under basic conditions. The reaction is usually catalyzed by sodium hydroxide. The process yields a mixture of products, but the desired ethenzamide can be isolated by recrystallization. The reaction is selective and the yield is generally good, around 70-85%.

Q: What industries use Ethenzamide (CAS: 938-73-8)?

Ethenzamide is used in the pharmaceutical industry for its potential as a drug intermediate. It is also employed in the polymer industry for its ability to act as a stabilizer and cross-linking agent. Additionally, it finds applications in the electronics industry as a component in sensors and semiconductors due to its chemical stability and reactivity.

Q: What precautions should be taken when handling Ethenzamide (CAS: 938-73-8)?

When handling Ethenzamide, use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Store it in a cool, dry place, away from strong acids, bases, and oxidizers. Use a fume hood during handling to avoid inhalation. In case of spill, contain the spill using an absorbent material and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.

Ethenzamide

Basic Information

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CAS Number

938-73-8

Molecular Formula

C9H11NO2

Molecular Weight

165.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

130.0 to 134.0 deg-C

Boiling Point

302°C at 760 mmHg

Density

1.1603 (rough estimate)

Water Solubility

<0.1 g/100 mL at 16 ºC

Flash Point

153.7 °C

Refractive Index

1.5620 (estimate)

SMILES

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CCOC1=CC=CC=C1C(=O)N

InChI

InChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11)

InChIKey

SBNKFTQSBPKMBZ-UHFFFAOYSA-N

LogP

1.1842

Topological Polar Surface Area

52.32 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

159

Safety Information

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GHS Hazard Pictograms

H303

Hazard Statement

H303 May be harmful if swallowed
Acute toxicity, oral

Toxicity

LD50 orally in mice: 1160 mg/kg (Starmer)

Synonyms & References

English

2-Ethoxybenzamide
Ethenzamide
Ethoxybenzamine
2-Ethoxybenzamine
o-Ethoxybenzamide
2-Aethoxy-benzamid
2-Aethoxy-benzoesaeure-amid
2-ethoxy-benzoic acid amide
Aethylaethersalicylsaeure-amid
Benzamide,2-ethoxy
Etamide
Etenzamide
Ethbenzamide
Ethosalicyl
O-Aethyl-salicylamid
Pirosolvina
2-Ethoxybenzoylamide
Benzamide, 2-ethoxy-
Ethenzamid
Anovigam
Trancalgyl
Protopyrin
Katagrippe
Etosalicyl
Etosalicil
Lucamide
Etocil
Eusal
Benzamide, o-ethoxy-
Etenzamide [DCIT]
Etenzamida [INN-Spanish]

MDL Number

MFCD00007977

Customs Code

29242995

FAQ

What are the physical and chemical properties of Ethenzamide (CAS: 938-73-8)?

Ethenzamide is a colorless or white crystalline solid with a molecular weight of approximately 132.13 g/mol. It has a melting point of 78-80°C and is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong bases. It is used in various applications due to its reactivity and solubility properties.

How is Ethenzamide (CAS: 938-73-8) typically synthesized?

Ethenzamide is typically synthesized through the amidation of ethyl acetoacetate with ammonia or an amine under basic conditions. The reaction is usually catalyzed by sodium hydroxide. The process yields a mixture of products, but the desired ethenzamide can be isolated by recrystallization. The reaction is selective and the yield is generally good, around 70-85%.

What industries use Ethenzamide (CAS: 938-73-8)?

Ethenzamide is used in the pharmaceutical industry for its potential as a drug intermediate. It is also employed in the polymer industry for its ability to act as a stabilizer and cross-linking agent. Additionally, it finds applications in the electronics industry as a component in sensors and semiconductors due to its chemical stability and reactivity.

What precautions should be taken when handling Ethenzamide (CAS: 938-73-8)?

When handling Ethenzamide, use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Store it in a cool, dry place, away from strong acids, bases, and oxidizers. Use a fume hood during handling to avoid inhalation. In case of spill, contain the spill using an absorbent material and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.