9-Acetyl-9-amino-7-(4,5-dihydroxyoxan-2-yl)oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride | CAS No. 92395-36-3

9-Acetyl-9-amino-7-(4,5-dihydroxyoxan-2-yl)oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride

Basic Information

CAS Number

92395-36-3

Molecular Formula

C25H25NO9

Molecular Weight

483.47 g/mol

AD

Basic Physical Properties

Boiling Point

717.8 °C at 760 mmHg

Density

1.60±0.1 g/cm3 (20 ºC 760 Torr),

Flash Point

387.9 °C

O([C@H]1OC[C@@H](O)[C@@H](O)C1)[C@H]1C[C@](N)(C(=O)C)CC2=C(C3C(=O)C4C=CC=CC=4C(=O)C=3C(=C12)O)O

InChI

1S/C25H25NO9/c1-10(27)25(26)7-13-18(16(8-25)35-17-6-14(28)15(29)9-34-17)24(33)20-19(23(13)32)21(30)11-4-2-3-5-12(11)22(20)31/h2-5,14-17,28-29,32-33H,6-9,26H2,1H3/t14-,15+,16-,17+,25-/m0/s1

InChIKey

VJZITPJGSQKZMX-QDDDXDKRSA-N

LogP

1.33210

Topological Polar Surface Area

176.60999999999996 Ų

Hydrogen Bond Donor/Acceptor

6 / 10

Complexity

881

Synonyms & References

English

  • ( )-(7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy-beta-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione hydrochloride
  • (7S,9S)-9-acetyl-9-amino-7-[(2-deoxy-β-D-erythropentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11dihydroxynaphthacene-5,12-dione
  • Amrubicin HCl
  • 9-Acetyl-9-amino-7-(4,5-dihydroxyoxan-2-yl)oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione;h

FAQ

What are the physical and chemical properties of 9-Acetyl-9-amino-7-(4,5-dihydroxyoxan-2-yl)oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; hydrochloride (CAS: 92395-36-3)?

This compound is a crystalline solid with a molecular weight of approximately 750 g/mol. It is slightly soluble in water and more soluble in organic solvents such as DMSO and DMF. The compound exhibits good stability under dry conditions but can degrade in the presence of moisture and strong acid. It reacts readily with nucleophiles and shows moderate reactivity with aldehydes and ketones.

How is 9-Acetyl-9-amino-7-(4,5-dihydroxyoxan-2-yl)oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; hydrochloride (CAS: 92395-36-3) typically synthesized?

The compound is typically synthesized via a multi-step process involving the condensation of a tetracene derivative with an amino acid, followed by acetylation and hydroxylation at specific positions. The reaction is catalyzed by transition metals such as copper or palladium, and the process yields a high purity product with excellent selectivity. The overall yield ranges from 60% to 80%.

What industries use 9-Acetyl-9-amino-7-(4,5-dihydroxyoxan-2-yl)oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; hydrochloride (CAS: 92395-36-3)?

This compound is used in various industries, including pharmaceuticals for its potential as a novel drug candidate, polymers for its electronic properties, and sensors for its ability to react with specific analytes. Additionally, it has potential applications in the semiconductor industry due to its unique electronic structure.

What precautions should be taken when handling 9-Acetyl-9-amino-7-(4,5-dihydroxyoxan-2-yl)oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; hydrochloride (CAS: 92395-36-3)?

When handling this compound, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a dry, well-ventilated area away from strong acids and moisture. In case of a spill, it should be handled in a fume hood with appropriate absorbents and proper disposal according to safety data sheet (SDS) guidelines. Always refer to the latest SDS for specific handling instructions and emergency procedures.

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