Proflavine | CAS No. 92-62-6

Proflavine

Basic Information

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CAS Number

92-62-6

Molecular Formula

C13H11N3

Molecular Weight

209.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

281° (Schpff); mp 288° (Albert)

Boiling Point

338.61°C (rough estimate)

Density

1.1847 (rough estimate)

Flash Point

292.9 °C

Refractive Index

1.6000 (estimate)

SMILES

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C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N

InChI

InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2

InChIKey

WDVSHHCDHLJJJR-UHFFFAOYSA-N

LogP

2.5524000000000004

pKa

9.65(at 20℃)

Topological Polar Surface Area

64.92999999999999 Å²

Hydrogen Bond Donor/Acceptor

4 / 3

Complexity

232

Safety Information

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Toxicity

LD50 s.c. in mice: 0.14 g/kg (Rubbo)

Synonyms & References

English

3,6-Acridinediamine
Acridine-3,6-diamine
Proflavine
Proflavin
3,6-Diaminoacridine
Isoflav base
Proflavinum
Proflavina
3,6-Diaminoacridinium
2,8-Diaminoacridinium
Proflavine [INN]
Progarmed
Profura
Proflavine hemisulfate
3,7-Diamino-5-azaanthracene
Proflavinum [INN-Latin]
Proflavina [INN-Spanish]
2,8-Diaminoacridine
2,8-Diaminoacridine (European)
Acridine, 3,6-diamino-
CY3RNB3K4T
WDVSHHCDHLJJJR-UHFFFAOY
Acridine, 3,6-diamino- (8CI)
Acriflavin A
MeSH ID: D011370
NCI60_004643
ALBB-024962
MFCD00005030
HY-B1741
PRL
1qvu

MDL Number

MFCD00005030

FAQ

What are the physical and chemical properties of Proflavine (CAS: 92-62-6)?

Proflavine (CAS: 92-62-6) is a yellow crystalline compound with a molecular weight of approximately 324.27 g/mol. It is slightly soluble in water but readily soluble in alcohol. Proflavine is relatively stable under normal conditions but can be hydrolyzed in the presence of strong acids or bases. It is used as a fungicide and in biological applications due to its dyeing properties.

How is Proflavine (CAS: 92-62-6) typically synthesized?

Proflavine (CAS: 92-62-6) can be synthesized by the condensation of 4-dimethylaminobenzaldehyde with 2,4-dichloroaniline. The reaction is typically performed in the presence of a catalyst like p-toluenesulfonic acid. The yield is moderate, and the reaction is selective for the formation of Proflavine.

What industries use Proflavine (CAS: 92-62-6)?

Proflavine (CAS: 92-62-6) is primarily used in the pharmaceutical industry as a preservative and dye. It is also utilized in the textile industry as a colorant. Additionally, it has applications in agriculture as a fungicide and in biological research for staining purposes.

What precautions should be taken when handling Proflavine (CAS: 92-62-6)?

When handling Proflavine (CAS: 92-62-6), proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a laboratory coat. Proflavine should be stored in a well-ventilated area away from heat sources. If a spill occurs, it should be managed carefully, and appropriate safety data sheets (SDS) should be consulted for specific procedures. Fume hoods should be used during handling to minimize inhalation risk.