(R)-1-benzylpiperidin-3-ol

Basic Information

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CAS Number

91599-81-4

Molecular Formula

C12H17NO

Molecular Weight

191.27 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

102°C/0.4mmHg

Density

1.07 g/mL at 25 °C

Refractive Index

n20/D 1.547(lit.)

Specific Rotation

-12 º (c=1 in MeOH)

SMILES

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C1CC(CN(C1)CC2=CC=CC=C2)O

InChI

InChI=1S/C12H17NO/c14-12-7-4-8-13(10-12)9-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2/t12-/m1/s1

InChIKey

UTTCOAGPVHRUFO-GFCCVEGCSA-N

LogP

1.6433

Topological Polar Surface Area

23.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

166

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Sensitiveness

Sensitive to air

Synonyms & References

English

(R)-1-Benzylpiperidin-3-ol
(R)-1-Benzyl-3-piperidinol
(R)-1-Benzyl-3-Hydroxypiperidine
(R)-(-)-1-Benzyl-3-hydroxypiperidine
1-BENZYL-3-PIPERIDINOL
(3R)-1-benzylpiperidin-3-ol
(R)-1-N-Benzyl-3-hydroxy-piperidine
3-Piperidinol,1-(phenylmethyl)-, (R)-
(R)-( pound inverted question mark)-1-Benzyl-3-hydroxypiperidinol
PubChem13101
1-Benzylpiperidine-3alpha-ol
UTTCOAGPVHRUFO-GFCCVEGCSA-N
AS06625
AB05871
(R)-N-BEN
(3R)-1-(Phenylmethyl)-3-piperidinol (ACI)
3-Piperidinol, 1-(phenylmethyl)-, (R)- (ZCI)
(3R)-1-Benzylpiperidin-3-ol
3-Piperidinol 1-(phenylmethyl)-, (3R)-
(R)-1-benzylpiperidin-3-ol
DB-030996
MFCD00274307
(R)-1-Benzyl-3-hydroxypiperidine
DTXSID60351227
R-1-Benzylpiperidin-3-ol
91599-81-4
AC-15326
DS-1746
SCHEMBL1787570
B4857
CS-W015846

MDL Number

MFCD00274307

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (R)-1-benzylpiperidin-3-ol (CAS: 91599-81-4)?

(R)-1-benzylpiperidin-3-ol (CAS: 91599-81-4) has a crystalline form with a molecular weight of approximately 217.27 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. The compound exhibits basic properties and can react with acidic compounds. It is stable under normal conditions but should be stored away from strong acids and bases.

How is (R)-1-benzylpiperidin-3-ol (CAS: 91599-81-4) typically synthesized?

(R)-1-benzylpiperidin-3-ol (CAS: 91599-81-4) can be synthesized via several routes, including the Wittig reaction or alkylation reactions. Common methods involve the use of benzyl bromide and piperidine, with a catalyst such as sodium hydride. The yield is typically around 70-80%, with good selectivity to the (R)-enantiomer.

What industries use (R)-1-benzylpiperidin-3-ol (CAS: 91599-81-4)?

(R)-1-benzylpiperidin-3-ol (CAS: 91599-81-4) is used in the pharmaceutical industry for the synthesis of drug candidates. It also finds applications in polymer chemistry for modifying polymer properties and in sensor technology for specific chemical detection. Its use in semiconductor manufacturing is less common but possible, depending on its functional groups.

What precautions should be taken when handling (R)-1-benzylpiperidin-3-ol (CAS: 91599-81-4)?

When handling (R)-1-benzylpiperidin-3-ol (CAS: 91599-81-4), it is advisable to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure the work is carried out in a well-ventilated hood to avoid inhalation. Spills should be cleaned up with absorbent material and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.