5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine

Basic Information

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CAS Number

91476-80-1

Molecular Formula

C6H9N3

Molecular Weight

123.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

322.8°C at 760 mmHg

SMILES

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C1CN2C=CN=C2CN1

InChI

InChI=1S/C6H9N3/c1-3-9-4-2-8-6(9)5-7-1/h2,4,7H,1,3,5H2

InChIKey

SWBUHQQTIPEPMK-UHFFFAOYSA-N

LogP

-0.013700000000000212

Topological Polar Surface Area

29.85 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

105

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

5,6,7,8-tetrahydroimidazo-[1,2-a]pyrazine
J-516492
EN300-63732
A843943
PS-5019
AB00991860-01
Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-
5H,6H,7H,8H-imidazo[1,2-a]pyrazine
91476-80-1
SY008392
AKOS009160915
5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine
SCHEMBL109208
AM804542
DTXSID10531779
SWBUHQQTIPEPMK-UHFFFAOYSA-N
5,6,7,8 tetrahydro-imidazo[1,2-a]pyrazine
FT-0603819
5,6,7,8-tetrahydroimidazo[1,2-alpha]pyrazine
CS-W019673
MFCD09701264
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, AldrichCPR
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
5,6,7,8tetrahydro-imidazo[1,2-a]pyrazine
5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRAZINE
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine hydrochloride
Imidazo[1,2-a]pyrazine,5,6,7,8-tetrahydro-
PubChem11365
IP1281
TRA0090603
TRA0014070

MDL Number

MFCD09701264

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine (CAS: 91476-80-1)?

5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine is a solid with a crystalline form. Its molecular weight is approximately 141.14 g/mol. This compound has a moderate solubility in common organic solvents like dichloromethane and acetonitrile but is poorly soluble in water. It is relatively stable under normal conditions but can react with strong acids or bases. The compound is not flammable and has a low vapor pressure.

How is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine (CAS: 91476-80-1) typically synthesized?

5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine can be synthesized via a multistep process involving the condensation of 1H-imidazole with malononitrile followed by hydrolysis. Commonly used catalysts include strong bases like sodium hydride. The reaction is typically carried out in an aprotic solvent such as dimethylformamide (DMF). The yield is usually around 70-80%, and high selectivity is achieved.

What industries use 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine (CAS: 91476-80-1)?

5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine is primarily used in the pharmaceutical industry for its potential as a ligand in metal complexes and as a precursor to various bioactive compounds. It also finds applications in polymer synthesis, where it can serve as a monomer, and in the development of sensors due to its chemical reactivity and stability.

What precautions should be taken when handling 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine (CAS: 91476-80-1)?

When handling 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, it is important to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from heat and ignition sources. Spills should be cleaned up using absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety guidelines.