Compound Q&A
How is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine (CAS: 91476-80-1) typically synthesized?
Answer
![5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine](https://static.chemtradehub.com/structs/914/91476-80-1-e566.webp "5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine")
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine can be synthesized via a multistep process involving the condensation of 1H-imidazole with malononitrile followed by hydrolysis. Commonly used catalysts include strong bases like sodium hydride. The reaction is typically carried out in an aprotic solvent such as dimethylformamide (DMF). The yield is usually around 70-80%, and high selectivity is achieved.
About
CAS No
91476-80-1
English Name
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
Molecular Formula
C6H9N3
Molecular Weight
123.159 g/mol
SMILES
C1CN2C=CN=C2CN1
InChIKey
SWBUHQQTIPEPMK-UHFFFAOYSA-N
Last Updated: 2025-10-08 00:58
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