3-(tert-Butyldimethylsilyloxy)glutaric anhydride

Basic Information

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CAS Number

91424-40-7

Molecular Formula

C11H20O4Si

Molecular Weight

244.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

79-81 °C

Boiling Point

302.4°C at 760 mmHg

Density

1.03

Flash Point

>113°(235°F)

Refractive Index

1.4510

SMILES

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CC(C)(C)[Si](C)(C)OC1CC(=O)OC(=O)C1

InChI

InChI=1S/C11H20O4Si/c1-11(2,3)16(4,5)15-8-6-9(12)14-10(13)7-8/h8H,6-7H2,1-5H3

InChIKey

RXAJGRHLLRGVSB-UHFFFAOYSA-N

LogP

2.2404

Topological Polar Surface Area

52.6 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

288

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Moisture Sensitive

Synonyms & References

English

3-(tert-Butyldimethylsilyloxy)glutaric anhydride
3-(t-BUTYLDIMETHYLSILOXY)GLUTARIC ANHYDRIDE
3-[(Tert-Butyldimethylsilyl)oxy] Pentanedioic Anhydride
3-[(tert-Butyldimethylsilyl)oxy]glutaric anhydride
4-[tert-butyl(dimethyl)silyl]oxyoxane-2,6-dione
Rosuvastatin J-3
: 3-(tert-Butyldimethylsilyloxy)glutaric anhydride
2H-Pyran-2,6(3H)-dione,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]dihydro-
3-[(tert-Butyldimethylsilyl)oxy]glutaricanhydride
4-((tert-Butyldimethylsilyl)oxy)dihydro-2H-pyran-2,6(3H)-dione
3-(tert-butyldimethylsilyloxy)glutaric anhydride,
4-(tert-butyldimethylsilyloxy)dihydro-2H-pyran-2,6(3H)-dione
4-[(tert-butyldimethylsilyl)oxy]oxane-2,6-dione
C11H20O4Si
RXAJGRHLLRGVSB-UHFFFAOYSA-N
BCP10931
AK
4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]dihydro-2H-pyran-2,6(3H)-dione (ACI)
3-(tert-Butyldimethylsilyloxy)glutaricanhydride
3-[(tert-Butyldimethyl silyl)oxy]glutaric anhydride
GS-3347
O11057
91424-40-7
CS-W012734
AKOS015900599
MFCD00075235
DTXSID40399829
SY017618
3-[(Tert-Butyldimethylsilyl)Oxy] Pentanedioic Anhydride
AC-769
3-[(tert-butyldimethylsilyl)oxy]pentanedioic anhydride

MDL Number

MFCD00075235

Customs Code

2931900090

FAQ

What are the physical and chemical properties of 3-(tert-Butyldimethylsilyloxy)glutaric anhydride (CAS: 91424-40-7)?

3-(tert-Butyldimethylsilyloxy)glutaric anhydride is a white crystalline solid with a molecular weight of approximately 298.4 g/mol. It has limited solubility in common organic solvents like acetone and ethanol. Chemically, it is highly reactive, especially under acidic conditions, making it suitable for a variety of synthetic reactions.

How is 3-(tert-Butyldimethylsilyloxy)glutaric anhydride (CAS: 91424-40-7) typically synthesized?

3-(tert-Butyldimethylsilyloxy)glutaric anhydride is typically synthesized through the condensation reaction of 3-(tert-butyldimethylsilyloxy)glutaric acid with a strong acid catalyst, such as sulfuric acid. The reaction provides excellent yield and selectivity, making it a preferred method in organic synthesis.

What industries use 3-(tert-Butyldimethylsilyloxy)glutaric anhydride (CAS: 91424-40-7)?

3-(tert-Butyldimethylsilyloxy)glutaric anhydride is widely used in the pharmaceutical industry for the synthesis of various drug intermediates. It also finds applications in polymer synthesis and as a sensor material due to its reactive nature and stability.

What precautions should be taken when handling 3-(tert-Butyldimethylsilyloxy)glutaric anhydride (CAS: 91424-40-7)?

When handling 3-(tert-Butyldimethylsilyloxy)glutaric anhydride, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed safety information.