Ropinirole | CAS No. 91374-21-9

Ropinirole

Basic Information

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CAS Number

91374-21-9

Molecular Formula

C16H24N2O

Molecular Weight

260.38 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

243-250 ºC

Boiling Point

410.5 °C at 760 mmHg

Density

1.04

Flash Point

202 °C

Refractive Index

1.538

SMILES

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CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1

InChI

InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)

InChIKey

UHSKFQJFRQCDBE-UHFFFAOYSA-N

LogP

2.845700000000001

Topological Polar Surface Area

32.34 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

287

Synonyms & References

English

Ropinirole
(Ropinirole )
2H-Indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-
4-(2-Dipropylaminoethyl)-1,3-dihydroindol-2-one
Ropinirole (as hydrochloride)
ROPINIROLE INTERMEIDATES:
Ropinirolum
Unii-030pyr8953
4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one (ACI)
NP 201
SKF 101468
4-[2-(dipropylamino)ethyl]-2,3-dihydro-1h-indol-2-one
Q420590
SCHEMBL35212
AB01563044_01
SPECTRUM1505178
4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one
STL454344
Pharmakon1600-01505178
ROPINIROLE [INN]
Tox21_110256_1
BRD-K15933101-003-07-9
UNII-030PYR8953
Lopac0_001101
Ropinirole [USAN:INN:BAN]
DB00268
BRD-K15933101-003-06-1
91374-21-9
Narapin
C07564
2H-Indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-

MDL Number

MFCD00864147

FAQ

What are the physical and chemical properties of Ropinirole (CAS: 91374-21-9)?

Ropinirole is a white to off-white crystalline powder with a molecular weight of approximately 279.31 g/mol. It is slightly soluble in water and has poor solubility in organic solvents. Ropinirole is relatively stable under normal storage conditions but undergoes slow hydrolysis in acidic and basic environments. It is mainly used as a levorotatory isomer (L-ropinirole).

How is Ropinirole (CAS: 91374-21-9) typically synthesized?

Ropinirole is synthesized via a multi-step process that includes reduction of a ketone, cyclization, and final ring-opening. Common starting materials include 4-(2-(4-(4-(2-(2-aminopropanoyl)phenyl)phenyl)phenoxy)ethoxy)benzaldehyde. The synthesis involves the use of catalysts like palladium and ligands, ensuring high selectivity and good yield. Detailed synthesis protocols can be found in the literature and patents.

What industries use Ropinirole (CAS: 91374-21-9)?

Ropinirole is primarily used in the pharmaceutical industry, particularly for the treatment of Parkinson's disease and restless legs syndrome. It is also used in some research contexts for studying dopamine receptor agonists. Its applications in the polymer and sensor industries are limited but ongoing research may expand its utility.

What precautions should be taken when handling Ropinirole (CAS: 91374-21-9)?

When handling Ropinirole, ensure the use of personal protective equipment (PPE) including gloves, goggles, and lab coats. Store it in a cool, dry place away from direct sunlight and heat sources. In case of spill, immediately clean up using appropriate absorbents and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.