Ropinirole(CAS: 91374-21-9)

Ropinirole is a white to off-white crystalline powder with a molecular weight of approximately 279.31 g/mol. It is slightly soluble in water and has poor solubility in organic solvents. Ropinirole is relatively stable under normal storage conditions but undergoes slow hydrolysis in acidic and basic environments. It is mainly used as a levorotatory isomer (L-ropinirole).

Ropinirole is synthesized via a multi-step process that includes reduction of a ketone, cyclization, and final ring-opening. Common starting materials include 4-(2-(4-(4-(2-(2-aminopropanoyl)phenyl)phenyl)phenoxy)ethoxy)benzaldehyde. The synthesis involves the use of catalysts like palladium and ligands, ensuring high selectivity and good yield. Detailed synthesis protocols can be found in the literature and patents.

Ropinirole is primarily used in the pharmaceutical industry, particularly for the treatment of Parkinson's disease and restless legs syndrome. It is also used in some research contexts for studying dopamine receptor agonists. Its applications in the polymer and sensor industries are limited but ongoing research may expand its utility.

When handling Ropinirole, ensure the use of personal protective equipment (PPE) including gloves, goggles, and lab coats. Store it in a cool, dry place away from direct sunlight and heat sources. In case of spill, immediately clean up using appropriate absorbents and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.