(S)-2-Methoxy-1-phenylethanamine

Basic Information

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CAS Number

91298-74-7

Molecular Formula

C9H13NO

Molecular Weight

151.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Boiling Point

230.2℃ at 760 mmHg

SMILES

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COCC(C1=CC=CC=C1)N

InChI

InChI=1S/C9H13NO/c1-11-7-9(10)8-5-3-2-4-6-8/h2-6,9H,7,10H2,1H3/t9-/m1/s1

InChIKey

CMTDMIYJXVBUDX-SECBINFHSA-N

LogP

1.3328000000000002

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

99.7

Safety Information

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Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

(S)-2-Methoxy-1-phenylethanamine
(1S)-2-methoxy-1-phenylethanamine
(S)-(+)-1-AMINO-1-PHENYL-2-METHOXYETHANE
(S)-a-(Methoxymethyl)benzenemethanamine
(αS)-α-(Methoxymethyl)benzenemethanamine (ACI)
Benzenemethanamine, α-(methoxymethyl)-, (S)- (ZCI)
(1S)-2-Methoxy-1-phenylethan-1-amine
(1S)-2-Methoxy-1-phenylethanamine
(1S)-2-Methoxy-1-phenylethylamine
(S)-(+)-1-Amino-1-phenyl-2-methoxyethane
(S)-1-Phenyl-2-methoxyethylamine
(S)-2-Methoxy-1-phenylethan-1-amine
(S)-2-Methoxy-1-phenylethylamine
L-Phenylglycinol methyl ether
EN300-6889890
BS-24834
(1S)-2-methoxy-1-phenylethylamine
(S)-(+)-1-amino-1-phenyl-2-methoxyethane, AldrichCPR
(S)-2-methoxy-1-phenylethan-1-amine
(S)-(+)-2-Methoxy-1-phenylethylamine
DTXSID90472055
MFCD01862273
(1S)-2-methoxy-1-phenylethan-1-amine
AKOS016842759
N12553
SCHEMBL57799
(s)-phenylglycinol methyl ether
91298-74-7
(1S)-2-Methoxy-1-phenyl-ethanamine
CS-0138293
CMTDMIYJXVBUDX-SECBINFHSA-N

MDL Number

MFCD01862273

FAQ

What are the physical and chemical properties of (S)-2-Methoxy-1-phenylethanamine (CAS: 91298-74-7)?

(S)-2-Methoxy-1-phenylethanamine is a colorless to white crystalline solid. It has a molecular weight of approximately 169.24 g/mol and a solubility of 2.9 g/100 mL in water at 20°C. It is slightly soluble in common organic solvents like ethanol and acetone. This compound is known for its good basicity and moderate reactivity, typically reacting with acids to form salts or esters.

How is (S)-2-Methoxy-1-phenylethanamine (CAS: 91298-74-7) typically synthesized?

(S)-2-Methoxy-1-phenylethanamine can be synthesized through kinetic resolution of racemic 2-phenylethylamine using chiral quinine as a resolving agent. The reaction involves treatment with trifluoroacetic acid to generate the hydrochloride salt, which is then hydrolyzed to obtain the desired enantiomer with high selectivity. This method provides good yields and is widely used in pharmaceutical and fine chemical industries.

What industries use (S)-2-Methoxy-1-phenylethanamine (CAS: 91298-74-7)?

(S)-2-Methoxy-1-phenylethanamine is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It also finds applications in the polymer industry for modifying the properties of polymers. Additionally, it is used in the development of sensors and as a chiral auxiliary in organic chemistry. This compound is less common in semiconductors but is still utilized in certain specialized applications.

What precautions should be taken when handling (S)-2-Methoxy-1-phenylethanamine (CAS: 91298-74-7)?

When handling (S)-2-Methoxy-1-phenylethanamine, it is important to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be managed in a fume hood to minimize inhalation risk. In case of a spill, immediately clean up with appropriate absorbent materials and ensure proper disposal. Always refer to the Safety Data Sheet (SDS) for specific handling and storage guidelines to ensure safety in the laboratory environment.