Compound Q&A
How is (S)-2-Methoxy-1-phenylethanamine (CAS: 91298-74-7) typically synthesized?
Answer
(S)-2-Methoxy-1-phenylethanamine can be synthesized through kinetic resolution of racemic 2-phenylethylamine using chiral quinine as a resolving agent. The reaction involves treatment with trifluoroacetic acid to generate the hydrochloride salt, which is then hydrolyzed to obtain the desired enantiomer with high selectivity. This method provides good yields and is widely used in pharmaceutical and fine chemical industries.
About
CAS No
91298-74-7
English Name
(S)-2-Methoxy-1-phenylethanamine
Molecular Formula
C9H13NO
Molecular Weight
151.21 g/mol
SMILES
COCC(C1=CC=CC=C1)N
InChIKey
CMTDMIYJXVBUDX-SECBINFHSA-N
Last Updated: 2025-10-28 10:54
