Fmoc-Arg-OH | CAS No. 91000-69-0

Fmoc-Arg-OH

Basic Information

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CAS Number

91000-69-0

Molecular Formula

C21H24N4O4

Molecular Weight

396.45 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

145-150 °C <br />145-160 °C (dec.)

Boiling Point

520.14°C (rough estimate)

Density

1.2722 (rough estimate)

Flash Point

No data available

Refractive Index

1.6620 (estimate)

Specific Rotation

9 º (c=1 DMF 24 ºC)

SMILES

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C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CCCN=C(N)N)C(=O)O

InChI

InChI=1S/C21H24N4O4/c22-20(23)24-11-5-10-18(19(26)27)25-21(28)29-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17-18H,5,10-12H2,(H,25,28)(H,26,27)(H4,22,23,24)/t18-/m0/s1

InChIKey

DVBUCBXGDWWXNY-SFHVURJKSA-N

LogP

2.2415700000000003

Topological Polar Surface Area

137.53 Å²

Hydrogen Bond Donor/Acceptor

6 / 8

Complexity

586

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Moisture Sensitive

Synonyms & References

English

FMOC-L-Arginine
N-alpha-9-Fluorenylmethoxycarbonyl-L-arginine
FMOC-Arg-OH
Fmoc-L-Arg-OH*H2O
N-α-Fmoc-L-Arginine
Nα-Fmoc-L-arginine
PARAGOS 300307
(2S)-5-(amidinoamino)-2-[(fluoren-9-ylmethoxy)carbonylamino]pentanoic acid
A-Fmoc-L-Arginine
Fmoc-Arg(Pmc)-OH
FMOC-L-ARG-OH
Nalpha-(9-Fluorenylmethoxycarbonyl)-L-arginine
Nalpha-Fmoc-L-arginine
Fmoc-Arg
Na-Fmoc-L-arginine
PubChem9999
N-
N-A-FMOC-L-ARGININE
KSC494E9B
DVBUCBXGDWWXNY-SFHVURJKSA-N
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-guanidino-pentanoic acid
AM81509
AB02141
(2S)-5-(diam
Fmoc-L-Arginine
N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-arginine (ACI)
(2S)-5-Carbamimidamido-2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)pentanoic acid
Fmoc-L-Arg-OH
Fmoc-L-arginine
N-FMOC-L-arginine
Nα-FMOC-L-arginine

MDL Number

MFCD00051770

Customs Code

29252900

FAQ

What are the physical and chemical properties of Fmoc-Arg-OH (CAS: 91000-69-0)?

Fmoc-Arg-OH (CAS: 91000-69-0) is a solid with a crystalline form. The molecular weight is approximately 440.46 g/mol. It is soluble in water and methanol. Fmoc-Arg-OH is known for its reactivity in peptide coupling reactions, particularly in solid-phase peptide synthesis.

How is Fmoc-Arg-OH (CAS: 91000-69-0) typically synthesized?

Fmoc-Arg-OH is typically synthesized via the solid-phase peptide synthesis method. The key steps involve protecting the amino group with the Fmoc protecting group, followed by the stepwise addition of Arginine. Common solvents include dichloromethane and triethylamine. The overall yield is around 80-90%.

What industries use Fmoc-Arg-OH (CAS: 91000-69-0)?

Fmoc-Arg-OH (CAS: 91000-69-0) is widely used in the pharmaceutical industry for the synthesis of peptide drugs. It is also utilized in the polymer industry for the modification of polymers and in the biosensor industry for developing biosensing devices.

What precautions should be taken when handling Fmoc-Arg-OH (CAS: 91000-69-0)?

When handling Fmoc-Arg-OH (CAS: 91000-69-0), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety instructions.