Quinoxaline | CAS No. 91-19-0

Quinoxaline

Basic Information

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CAS Number

91-19-0

Molecular Formula

C8H6N2

Molecular Weight

130.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

29-32 °C

Boiling Point

220-223 °C

Density

1.124 g/mL at 25 °C

Solubility

alcohol: freely soluble(lit.)

Refractive Index

nD48 1.6231

SMILES

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c1ccc2nccnc2c1

InChI

InChI=1S/C8H6N2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-6H

InChIKey

XSCHRSMBECNVNS-UHFFFAOYSA-N

LogP

1.6297999999999997

pKa

0.56(at 20℃)

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

99.8

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Sensitiveness

Sensitive to air

Synonyms & References

English

Quinoxaline
1,4-Benzodiazine
1,4-Diazanaphthalene
Benzoparadiazine
Benzopyrazine
Phenopiazine
Phenpiazine
Quinazine
Benzo[a]pyrazine
1,4-Naphthyridine
Chinoxalin
Benzo(a)pyrazine
QM4AR6M6T8
XSCHRSMBECNVNS-UHFFFAOYSA-N
Quinoxaline, 98+%
Quinoxaline, homopolymer
chinoxaline
1,4-Quinoxaline
Quinoxaline, 99%
Quinoxaline (8CI,9CI)
Quinoxaline, >=95.0%
DSSTox_RID_83507
DSSTox_
quinoxaline

MDL Number

MFCD00006719

Customs Code

29339990

FAQ

What are the physical and chemical properties of Quinoxaline (CAS: 91-19-0)?

Quinoxaline (CAS: 91-19-0) is a crystalline solid with a molecular weight of approximately 129.12 g/mol. It has a high solubility in organic solvents such as ethanol and acetone but is only slightly soluble in water. Chemically, it is an amphoteric compound, meaning it can act as both an acid and a base. It is known for its reactivity towards nucleophiles and electrophiles, making it useful in various chemical reactions.

How is Quinoxaline (CAS: 91-19-0) typically synthesized?

Quinoxaline (CAS: 91-19-0) can be synthesized via a number of routes, but one common method involves the condensation of acridine-2-carboxaldehyde and acridine-2-carbonitrile. This reaction typically requires a catalyst like phosphoric acid and is carried out in an organic solvent. The yield and selectivity of the synthesis can be controlled by optimizing reaction conditions such as temperature and concentration.

What industries use Quinoxaline (CAS: 91-19-0)?

Quinoxaline (CAS: 91-19-0) is used in various industries. In pharmaceuticals, it serves as a precursor to medicinal compounds. In the polymer industry, it can be used to improve the properties of plastic materials. Additionally, it finds applications in the manufacturing of sensors and semiconductors, where its electronic properties are utilized.

What precautions should be taken when handling Quinoxaline (CAS: 91-19-0)?

When handling Quinoxaline (CAS: 91-19-0), appropriate personal protective equipment (PPE) such as gloves and safety goggles should be worn. The compound should be used in a well-ventilated area or a fume hood to minimize exposure. In case of a spill, it is important to clean up using appropriate absorbents and to dispose of materials according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and safety information.