Methyl 6-methyl-3-piperidinecarboxylate

Basic Information

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CAS Number

908245-03-4

Molecular Formula

C8H15NO2

Molecular Weight

157.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CC1CCC(CN1)C(=O)OC

InChI

InChI=1S/C8H15NO2/c1-6-3-4-7(5-9-6)8(10)11-2/h6-7,9H,3-5H2,1-2H3

InChIKey

AJUGGHOVBBTHCD-UHFFFAOYSA-N

LogP

0.5474999999999999

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

147

Synonyms & References

English

MFCD13178893
AS-46543
6-Methyl-piperidine-3-carboxylic acid methyl ester
SB20885
SCHEMBL599383
DTXSID20655258
1009376-88-8
(3r,6r)-3-piperidinecarboxylic acid, 6-methyl-, methyl ester
EN300-1069341
SB20883
A860697
SB22048
Methyl 6-methylpiperidine-3-carboxylate
rel-(3R,6R)-6-Methylpiperidine-3-carboxylic acid methyl ester
PB35041
FT-0762553
rel-(Methyl (3R,6S)-6-methylpiperidine-3-carboxylate)
Methyl6-methylpiperidine-3-carboxylate
CS1674
SB22047
SY297322
methyl (3RS,6RS)-6-methylpiperidine-3-carboxylate
methyl cis-2-methylpiperidine-5-carboxylate
MFCD21648274
BCP25619
SB22045
SB30092
6-methyl-3-piperidinecarboxylic acid methyl ester
SY096929
908245-03-4
1009376-91-3

MDL Number

MFCD13178893

FAQ

What are the physical and chemical properties of Methyl 6-methyl-3-piperidinecarboxylate (CAS: 908245-03-4)?

Methyl 6-methyl-3-piperidinecarboxylate is a white crystalline solid with a molecular weight of approximately 156.24 g/mol. It has a low water solubility but is soluble in common organic solvents like ethanol and acetone. The compound is relatively stable but reacts with strong bases to form piperidines. It exhibits a pKa of about 12.5.

How is Methyl 6-methyl-3-piperidinecarboxylate (CAS: 908245-03-4) typically synthesized?

Methyl 6-methyl-3-piperidinecarboxylate is typically synthesized via the reaction of 6-methyl-3-piperidone with methyl bromoacetate in the presence of a base like potassium carbonate. The reaction is carried out in an aprotic solvent such as N,N-dimethylformamide (DMF) at room temperature, yielding high selectivity and good yield.

What industries use Methyl 6-methyl-3-piperidinecarboxylate (CAS: 908245-03-4)?

Methyl 6-methyl-3-piperidinecarboxylate is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry as a precursor for the production of functionalized piperidine derivatives. Additionally, it finds applications in the sensor and semiconductor industries due to its unique chemical properties.

What precautions should be taken when handling Methyl 6-methyl-3-piperidinecarboxylate (CAS: 908245-03-4)?

When handling Methyl 6-methyl-3-piperidinecarboxylate, safety goggles and gloves should be worn. It is recommended to work in a fume hood due to its potential volatility. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.