Methyl 6-methyl-3-piperidinecarboxylate(CAS: 908245-03-4)

Methyl 6-methyl-3-piperidinecarboxylate is a white crystalline solid with a molecular weight of approximately 156.24 g/mol. It has a low water solubility but is soluble in common organic solvents like ethanol and acetone. The compound is relatively stable but reacts with strong bases to form piperidines. It exhibits a pKa of about 12.5.

Methyl 6-methyl-3-piperidinecarboxylate is typically synthesized via the reaction of 6-methyl-3-piperidone with methyl bromoacetate in the presence of a base like potassium carbonate. The reaction is carried out in an aprotic solvent such as N,N-dimethylformamide (DMF) at room temperature, yielding high selectivity and good yield.

Methyl 6-methyl-3-piperidinecarboxylate is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry as a precursor for the production of functionalized piperidine derivatives. Additionally, it finds applications in the sensor and semiconductor industries due to its unique chemical properties.

When handling Methyl 6-methyl-3-piperidinecarboxylate, safety goggles and gloves should be worn. It is recommended to work in a fume hood due to its potential volatility. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.