Polidocanol | CAS No. 9043-30-5

Q: What are the physical and chemical properties of Polidocanol (CAS: 9043-30-5)?

Polidocanol is a white to off-white crystalline powder. It has a molecular weight of approximately 612.6 g/mol and a melting point of around 143-145°C. Solubility in water is low, and it is moderately soluble in ethanol. Polidocanol is not highly reactive under normal conditions but is known to form salts easily. It has good compatibility with other polar solvents and is used in various formulations.

Q: How is Polidocanol (CAS: 9043-30-5) typically synthesized?

Polidocanol is synthesized through the condensation of sorbitol with alkylene oxides. The reaction is catalyzed by a strong acid, such as sulfuric acid. The process involves the stepwise addition of ethylene oxide to sorbitol to form the desired polyoxyethylene derivative. The reaction is carried out at elevated temperatures to improve the selectivity and yield of the product.

Q: What industries use Polidocanol (CAS: 9043-30-5)?

Polidocanol is widely used in the pharmaceutical industry, particularly in the formulation of sclerosing agents for the treatment of varicose veins. It is also utilized in the production of foam dressings and other topical treatments. Additionally, it has applications in the polymer industry for the production of biodegradable polymers. Polidocanol is sometimes used in the food industry as a foaming agent and in the cosmetics industry as a thickener and stabilizer.

Q: What precautions should be taken when handling Polidocanol (CAS: 9043-30-5)?

When handling Polidocanol, it is important to wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Ensure adequate ventilation and work in a fume hood. Store Polidocanol in a cool, well-ventilated place, away from direct sunlight and heat sources. In case of a spill, clean up immediately using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.

Polidocanol

Basic Information

View in Editor

CAS Number

9043-30-5

Molecular Formula

C30H62O10

Molecular Weight

582.82 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Melting Point

41-45 °C

Boiling Point

100 °C

Density

0.999 g/mL±0.002 g/mL at 20 °C

Solubility

H2O: 40 mg/mL at 20 °C, clear, colorless

Refractive Index

n20/D 1.461±0.001

Vapor Pressure

<1 mm Hg ( 20 °C)

SMILES

View in Editor

CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

InChI

InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3

InChIKey

ONJQDTZCDSESIW-UHFFFAOYSA-N

LogP

4.049000000000006

Topological Polar Surface Area

103.30000000000003 Å²

Hydrogen Bond Donor/Acceptor

1 / 10

Complexity

431

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Synonyms & References

English

Poly(oxy-1,2-ethanediyl),a-isotridecyl-w-hydroxy-
Anapoe-C13E8
GENAPOL(R) X-080
Polyethylene Glycol
Polyethylene Glycol Monoisotridecyl Ether
TO-5
Anapoe-C<SUB>13<
BRIJ 35
BRIJ 35(R)
BRIJ 35(TM)
BRIJ(R) 35
BRIJ(TM) 35
C12 E9
C12E23
GENAPOL X-80
genapolx080
POLIDOCANOL
SUB>
SUB>E<SUB>8<
Iso-tridecyl alchohol polyglycol ether (8EO)
Polidocanol [INN:DCF:JAN]
NCGC00166290-02
BRD-K35798650-001-01-4
0AWH8BFG9A
N1204
POLYETHYLENE GLYCOL MONOLAURYL ETHER (N=9)
10XBIO
Genapol X080
SR-01000944476
CAS-3055-99-0
NS00013822

MDL Number

MFCD00163738

FAQ

What are the physical and chemical properties of Polidocanol (CAS: 9043-30-5)?

Polidocanol is a white to off-white crystalline powder. It has a molecular weight of approximately 612.6 g/mol and a melting point of around 143-145°C. Solubility in water is low, and it is moderately soluble in ethanol. Polidocanol is not highly reactive under normal conditions but is known to form salts easily. It has good compatibility with other polar solvents and is used in various formulations.

How is Polidocanol (CAS: 9043-30-5) typically synthesized?

Polidocanol is synthesized through the condensation of sorbitol with alkylene oxides. The reaction is catalyzed by a strong acid, such as sulfuric acid. The process involves the stepwise addition of ethylene oxide to sorbitol to form the desired polyoxyethylene derivative. The reaction is carried out at elevated temperatures to improve the selectivity and yield of the product.

What industries use Polidocanol (CAS: 9043-30-5)?

Polidocanol is widely used in the pharmaceutical industry, particularly in the formulation of sclerosing agents for the treatment of varicose veins. It is also utilized in the production of foam dressings and other topical treatments. Additionally, it has applications in the polymer industry for the production of biodegradable polymers. Polidocanol is sometimes used in the food industry as a foaming agent and in the cosmetics industry as a thickener and stabilizer.

What precautions should be taken when handling Polidocanol (CAS: 9043-30-5)?

When handling Polidocanol, it is important to wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Ensure adequate ventilation and work in a fume hood. Store Polidocanol in a cool, well-ventilated place, away from direct sunlight and heat sources. In case of a spill, clean up immediately using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.