How is Polidocanol (CAS: 9043-30-5) typically synthesized?

Polidocanol is synthesized through the condensation of sorbitol with alkylene oxides. The reaction is catalyzed by a strong acid, such as sulfuric acid. The process involves the stepwise addition of ethylene oxide to sorbitol to form the desired polyoxyethylene derivative. The reaction is carried out at elevated temperatures to improve the selectivity and yield of the product.