N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine

Basic Information

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CAS Number

90390-11-7

Molecular Formula

C9H10F3N

Molecular Weight

189.18 g/mol

Basic Physical Properties

Boiling Point

187.0 ºC

Density

1.149

Flash Point

66.9 ºC

SMILES

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CNCC1=CC=C(C=C1)C(F)(F)F

InChI

InChI=1S/C9H10F3N/c1-13-6-7-2-4-8(5-3-7)9(10,11)12/h2-5,13H,6H2,1H3

InChIKey

YMSMEZAYZIYFGA-UHFFFAOYSA-N

LogP

2.4248000000000003

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

147

Synonyms & References

English

N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine
N-Methyl-4-(trifluoromethyl)benzylamine
Benzenemethanamine,N-methyl-4-(trifluoromethyl)-
N-Methyl-N-[4-(Trifluoromethyl)Benzyl]Amine
N-methyl-1-[4-(trifluoromethyl)phenyl]methanamine(SALTDATA: FREE)
N-[4-(Trifluoromethyl)benzyl]-N-methylamine
Benzenemethanamine, N-methyl-4-(trifluoromethyl)-
N-methyl-1-[4-(trifluoromethyl)phenyl]methanamine
methyl({[4-(trifluoromethyl)phenyl]methyl})amine
methyl([[4-(trifluoromethyl)phenyl]methyl])amine
YMSMEZAYZIYFGA-UHFFFAOYSA-N
SBB090921
4-trifluoromethyl-N-methylbenzyl
N-Methyl-4-(trifluoromethyl)benzenemethanamine (ACI)
(Methyl)[[4-(trifluoromethyl)phenyl]methyl]amine
4-Trifluoromethyl-N-methylbenzylamine
Methyl(4-trifluoromethylbenzyl)amine
N-Methyl-N-[4-(Trifluoromethyl)benzyl]amine
n-methyl-n-[4-(trifluoromethyl)benzyl]amine
EN300-07821
BS-13755
SCHEMBL296280
NCGC00374089-01
90390-11-7
Methyl-(4-trifluoromethyl-benzyl)-amine
90389-03-0
BYQVYJYCBHYVPJ-UHFFFAOYSA-N
CS-0077585
CHEMBL1178152
MFCD04115411
AC-2745

MDL Number

MFCD04115411

Customs Code

2921499090

FAQ

What are the physical and chemical properties of N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine (CAS: 90390-11-7)?

N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine is a colorless or white crystalline solid with a molecular weight of approximately 279.12 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. The compound is moderately reactive, especially towards nucleophilic reagents. It is often used in synthesis due to its stability under basic conditions.

How is N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine (CAS: 90390-11-7) typically synthesized?

N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine is typically synthesized via a multistep process involving the protection of the amine group, followed by coupling of the 4-(trifluoromethyl)benzyl halide with an amine in the presence of a suitable base. Commonly used catalysts include triphenylphosphine and imidazoles. The yield is usually around 70-80%, with high selectivity for the desired product.

What industries use N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine (CAS: 90390-11-7)?

N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine is used primarily in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). It is also utilized in the polymer industry for the development of advanced materials, in the semiconductor industry for electronic applications, and in analytical chemistry for sensors and detectors.

What precautions should be taken when handling N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine (CAS: 90390-11-7)?

When handling N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine, it is essential to wear appropriate personal protective equipment, including gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be rinsed with water. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.