Compound Q&A

How is N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine (CAS: 90390-11-7) typically synthesized?

Answer

N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine
N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine is typically synthesized via a multistep process involving the protection of the amine group, followed by coupling of the 4-(trifluoromethyl)benzyl halide with an amine in the presence of a suitable base. Commonly used catalysts include triphenylphosphine and imidazoles. The yield is usually around 70-80%, with high selectivity for the desired product.

About

CAS No 90390-11-7
English Name N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine
Molecular Formula C9H10F3N
Molecular Weight 189.18 g/mol
SMILES CNCC1=CC=C(C=C1)C(F)(F)F
InChIKey YMSMEZAYZIYFGA-UHFFFAOYSA-N
Last Updated: 2025-10-22 12:37

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