2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Basic Information

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CAS Number

89992-70-1

Molecular Formula

C9H18ClN2OP

Molecular Weight

236.68 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Nitriles

Agricultural Chemicals Pesticides Insecticides

Basic Physical Properties

Boiling Point

103-105℃/0.08mm

Density

1.061

Flash Point

110 ºC

Solubility

Miscible with chloroform and dichloromethane.

Refractive Index

1.476-1.48

SMILES

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CC(C)N(C(C)C)P(OCCC#N)Cl

InChI

InChI=1S/C9H18ClN2OP/c1-8(2)12(9(3)4)14(10)13-7-5-6-11/h8-9H,5,7H2,1-4H3

InChIKey

QWTBDIBOOIAZEF-UHFFFAOYSA-N

LogP

3.50118

Complexity

194

Safety Information

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GHS Hazard Pictograms

H250

H314

Hazard Statement

H250 Catches fire spontaneously if exposed to air
Pyrophoric liquids; Pyrophoric solids

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

2-Cyanoethyl-N,N-diisopropylamidochlorophosphite
2-Cyanoethyl diisopropylchlorophosphoramidite
2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
3-[chloro-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
Cyanoethyl N,N-Diisopropyl Phosphoamidochloridite
Chloro(diisopropylamino)-β-cyanoethoxyphosphine
Chloro(diisopropylamino)-beta-cyanoethoxyphosphine
2-cyanoethyl-N,N-diisopropylchlorophosphoramidite
Phosphoramidochloridous acid, bis(1-methylethyl)-, 2-cyanoethyl ester
3-((chloro(diisopropylamino)phosphino)oxy)propanenitrile
2-Cyanoethoxy(diisopropylamino)chlorophosphine
3-[chloro-(diisopropylamino)phosphanyl]oxypropanenitrile
QWTBDIBOOIAZEF-UHFFFAOYSA-N
ZX
Phosphoramidochloridous acid, bis(1-methylethyl)-, 2-cyanoethyl ester (9CI)
(2-Cyanoethoxy)(diisopropylamino)chlorophosphane
(2-Cyanoethoxy)(Diisopropylamino)chlorophosphine
(2-Cyanoethoxy)(N,N-diisopropylamino)chlorophosphine
(2-O-Cyanoethyl)(N,N-diisopropylamino)chlorophosphine
2-Cyanoethyl diisopropylphosphoramidochloridite
2-Cyanoethyl N,N-diisopropylchlorophosphoroamidite
2-Cyanoethyl N,N-diisopropylphosphoramidochloridite
3-((Chloro(diisopropylamino)phosphino)oxy)propanenitrile
3-[[(Chloro)(diisopropylamino)phosphanyl]oxy]propanenitrile
Amidite reagent
Chloro(2-cyanoethoxy)(diisopropylamino)phosphine
Chloro(β-cyanoethoxy)(diisopropylamino)phosphine
Cyanoethyl-N,N-diisopropylchlorophosphoramidite
N,N-Diisopropylamino-2-cyanoethoxychlorophosphine
β-Cyanoethyl N,N-diisopropylamidochlorophosphite
C9H18ClN2OP

MDL Number

MFCD00011544

Customs Code

29299090

FAQ

What are the physical and chemical properties of 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite (CAS: 89992-70-1)?

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite is a white crystalline solid with a molecular weight of approximately 284.8 g/mol. It is soluble in common organic solvents like dichloromethane and acetonitrile. The compound is reactive towards nucleophiles, particularly in phosphoramidite reactions, and is used in organic synthesis and solid-phase synthesis.

How is 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite (CAS: 89992-70-1) typically synthesized?

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite is typically synthesized through the reaction of diisopropyl chlorophosphorochloridate with 2-cyanoethyl isopropylamine. The reaction proceeds via a nucleophilic substitution mechanism, yielding a highly reactive phosphoramidite. The process requires careful control of temperature and solvent to ensure high yield and selectivity.

What industries use 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite (CAS: 89992-70-1)?

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite finds applications in the pharmaceutical industry for synthetic organic chemistry, particularly in solid-phase peptide and oligonucleotide synthesis. It is also used in polymer chemistry for functionalizing surfaces and in semiconductor manufacturing for photolithography processes.

What precautions should be taken when handling 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite (CAS: 89992-70-1)?

When handling 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite, ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated hood or fume hood to avoid inhalation of vapors. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.