2-Cyanoethyl N,N-diisopropylchlorophosphoramidite(CAS: 89992-70-1)

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite is a white crystalline solid with a molecular weight of approximately 284.8 g/mol. It is soluble in common organic solvents like dichloromethane and acetonitrile. The compound is reactive towards nucleophiles, particularly in phosphoramidite reactions, and is used in organic synthesis and solid-phase synthesis.

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite is typically synthesized through the reaction of diisopropyl chlorophosphorochloridate with 2-cyanoethyl isopropylamine. The reaction proceeds via a nucleophilic substitution mechanism, yielding a highly reactive phosphoramidite. The process requires careful control of temperature and solvent to ensure high yield and selectivity.

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite finds applications in the pharmaceutical industry for synthetic organic chemistry, particularly in solid-phase peptide and oligonucleotide synthesis. It is also used in polymer chemistry for functionalizing surfaces and in semiconductor manufacturing for photolithography processes.

When handling 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite, ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated hood or fume hood to avoid inhalation of vapors. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.