7-Bromoquinazoline

Basic Information

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CAS Number

89892-22-8

Molecular Formula

C8H5BrN2

Molecular Weight

209.05 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Refractive Index

1.685

SMILES

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C1=CC2=CN=CN=C2C=C1Br

InChI

InChI=1S/C8H5BrN2/c9-7-2-1-6-4-10-5-11-8(6)3-7/h1-5H

InChIKey

KMVULHBAEVRKCP-UHFFFAOYSA-N

LogP

2.3923000000000005

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

140

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

7-Bromoquinazoline
Quinazoline, 7-bromo-
7-Brom-chinazolin
7-Bromo-quinazoline
Quinazoline,7-bromo
PubChem14663
PubChem14661
7-bromoquinazoline, AldrichCPR
KMVULHBAEVRKCP-UHFFFAOYSA-N
PB23522
FCH1385446
SY096991
BC003900
ST2412525
AX8041027
AB1011688
AB0027435
W9266
AM20050452
A1075
7-Bromoquinazoline (ACI)
7-bromoquinazoline
DTXSID30458338
SCHEMBL1426869
CS-W008870
AKOS015835910
J-519175
EN300-111920
AC-23010
89892-22-8
MFCD07778500

MDL Number

MFCD07778500

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 7-Bromoquinazoline (CAS: 89892-22-8)?

7-Bromoquinazoline is a crystalline solid with a molecular weight of approximately 224.07 g/mol. It has a low water solubility and is moderately soluble in organic solvents like methanol and ethanol. This compound is reactive towards nucleophiles and can undergo substitution reactions. It is also susceptible to hydrolysis under basic conditions.

How is 7-Bromoquinazoline (CAS: 89892-22-8) typically synthesized?

7-Bromoquinazoline can be synthesized via the bromination of quinazoline in the presence of a base like sodium hydride. Another method involves the coupling of 7-aminoquinazoline with bromine in an appropriate solvent. These reactions typically yield 7-Bromoquinazoline with good selectivity and yield, though careful control of reaction conditions is necessary to achieve high purity.

What industries use 7-Bromoquinazoline (CAS: 89892-22-8)?

7-Bromoquinazoline finds applications in the pharmaceutical industry due to its potential as a bioactive compound. It is also studied in the field of materials science for its use in the development of sensors and semiconductors. Additionally, it is used in the synthesis of other organic compounds for various industrial applications.

What precautions should be taken when handling 7-Bromoquinazoline (CAS: 89892-22-8)?

When handling 7-Bromoquinazoline, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or fume hood to minimize inhalation risks. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials and disposing of the waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.