7-Bromoquinazoline(CAS: 89892-22-8)

7-Bromoquinazoline is a crystalline solid with a molecular weight of approximately 224.07 g/mol. It has a low water solubility and is moderately soluble in organic solvents like methanol and ethanol. This compound is reactive towards nucleophiles and can undergo substitution reactions. It is also susceptible to hydrolysis under basic conditions.

7-Bromoquinazoline can be synthesized via the bromination of quinazoline in the presence of a base like sodium hydride. Another method involves the coupling of 7-aminoquinazoline with bromine in an appropriate solvent. These reactions typically yield 7-Bromoquinazoline with good selectivity and yield, though careful control of reaction conditions is necessary to achieve high purity.

7-Bromoquinazoline finds applications in the pharmaceutical industry due to its potential as a bioactive compound. It is also studied in the field of materials science for its use in the development of sensors and semiconductors. Additionally, it is used in the synthesis of other organic compounds for various industrial applications.

When handling 7-Bromoquinazoline, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or fume hood to minimize inhalation risks. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials and disposing of the waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.