5-Bromo-2-hydroxy-3-methylpyridine

Basic Information

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CAS Number

89488-30-2

Molecular Formula

C6H6BrNO

Molecular Weight

188.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

170.0 to 174.0 deg-C

Density

1.5296 (rough estimate)

Flash Point

132.3℃

Refractive Index

1.5500 (estimate)

SMILES

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CC1=CC(=CNC1=O)Br

InChI

InChI=1S/C6H6BrNO/c1-4-2-5(7)3-8-6(4)9/h2-3H,1H3,(H,8,9)

InChIKey

HXPMRPRBABWPKL-UHFFFAOYSA-N

LogP

1.85812

Topological Polar Surface Area

33.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

205

Safety Information

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GHS Hazard Pictograms

H302

H315

H318

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

5-Bromo-3-methylpyridin-2(1H)-one
5-Bromo-2-hydroxy-3-methylpyridine
2-Chloro-5-hydroxypyridine
5-Bromo-2-hydroxy-3-picoline
5-bromo-3-methyl-1H-pyridin-2-one
5-bromo-3-methylpyridin-2-ol
5-Bromo-3-methyl-2-pyridinol
5-Bromo-3-methyl-2-pyridone
5-bromo-3-methyl-pyridin-2-ol
2-hydroxy-5-bromo-3-picoline
2-hydroxy-3-methyl-5-bromopyridine
2(1H)-PYRIDINONE, 5-BROMO-3-METHYL-
HXPMRPRBABWPKL-UHFFFAOYSA-N
5-BROMO-3-METHYL-2-HYDROXYPYRIDINE
5-Bromo-2-hydroxy-3-picoline (5-Bromo-2-hydroxy-3-methylpyridine)
NSC142314
Pu
2(1H)-Pyridone, 5-bromo-3-methyl- (7CI)
5-Bromo-3-methyl-2(1H)-pyridinone (ACI)
5-Bromo-3-methyl-1H-pyridin-2-one
5-Bromo-3-methyl-2-hydroxypyridine
5-Bromo-3-methylpyridin-2-ol
NSC 142314
NSC-142314
DTXSID70301314
BCP22176
5-bromo-2-hydroxy-3-methyl pyridine
J-517038
AE-018/31855039
89488-30-2
B2797

MDL Number

MFCD03427657

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-Bromo-2-hydroxy-3-methylpyridine (CAS: 89488-30-2)?

5-Bromo-2-hydroxy-3-methylpyridine (CAS: 89488-30-2) is a crystalline solid with a molecular weight of approximately 243.04 g/mol. It has a solubility of about 0.5 g/100 mL in water and is relatively stable in air. This compound can undergo substitution reactions and can be used as a precursor in organic synthesis.

How is 5-Bromo-2-hydroxy-3-methylpyridine (CAS: 89488-30-2) typically synthesized?

5-Bromo-2-hydroxy-3-methylpyridine can be synthesized via bromination of 2-hydroxy-3-methylpyridine using bromine in the presence of a Lewis acid catalyst. The yield is typically around 70-80%, with good selectivity towards the brominated product.

What industries use 5-Bromo-2-hydroxy-3-methylpyridine (CAS: 89488-30-2)?

5-Bromo-2-hydroxy-3-methylpyridine is used in the pharmaceutical and chemical industries for the preparation of intermediates and drugs. It also finds applications in the synthesis of sensors and semiconductors as a functional group modification reagent.

What precautions should be taken when handling 5-Bromo-2-hydroxy-3-methylpyridine (CAS: 89488-30-2)?

When handling 5-Bromo-2-hydroxy-3-methylpyridine, it is important to use appropriate personal protective equipment (PPE) including gloves, lab coat, and safety goggles. Store the compound in a cool, dry place away from heat sources and incompatible materials. In case of spill, handle it with care and refer to the Safety Data Sheet (SDS) for specific instructions.