3-Methoxy-5-methylpyrazin-2-amine

Basic Information

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CAS Number

89464-87-9

Molecular Formula

C6H9N3O

Molecular Weight

139.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CC1=CN=C(C(=N1)OC)N

InChI

InChI=1S/C6H9N3O/c1-4-3-8-5(7)6(9-4)10-2/h3H,1-2H3,(H2,7,8)

InChIKey

NIQNPTQRAGJGPS-UHFFFAOYSA-N

LogP

0.3758200000000001

Topological Polar Surface Area

61.03 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

109

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

3-Methoxy-5-methylpyrazin-2-amine
2-AMINO-3-METHOXY-5-METHYLPYRAZINE
2-Pyrazinamine,3-methoxy-5-methyl-
NIQNPTQRAGJGPS-UHFFFAOYSA-N
3-methoxy-5-methyl-2-pyrazinamine
5-methyl-3-methoxypyrazin-2-amine
3-methoxy-5-methylpyrazine-2-amine
SBB086077
FCH869685
3-methoxy-5-methylpyrazine-2-ylamine
3-Methoxy-5-methyl-pyrazin-2-ylamine
3-methoxy-5-methyl-pyrazine-2-ylamine
SB17877
ST24018
3-Methoxy-5-methyl-2-pyrazinamine (ACI)
Pyrazinamine, 3-methoxy-5-methyl- (9CI)
Pyrazine, 2-amino-3-methoxy-5-methyl- (7CI)
2-Amino-3-methoxy-5-methylpyrazine
3-methoxy-5-methylpyrazin-2-amine
C77014
CS-W021954
SCHEMBL91464
AKOS006327116
DS-17806
SY114293
MFCD09750038
89464-87-9
DTXSID90443624

MDL Number

MFCD09750038

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 3-Methoxy-5-methylpyrazin-2-amine (CAS: 89464-87-9)?

3-Methoxy-5-methylpyrazin-2-amine (CAS: 89464-87-9) is a crystalline solid with a molecular weight of approximately 165.21 g/mol. It has a high solubility in organic solvents such as ethanol and acetone. Chemically, it is stable under normal conditions but reacts with strong acids and bases to form derivatives. It has limited reactivity towards electrophiles and nucleophiles, making it a versatile compound in organic synthesis.

How is 3-Methoxy-5-methylpyrazin-2-amine (CAS: 89464-87-9) typically synthesized?

3-Methoxy-5-methylpyrazin-2-amine is typically synthesized via a multistep process. The first step involves the condensation of methylpyrazine with methoxyamine hydrochloride using a basic catalyst like sodium hydroxide. This step is followed by the reduction of the resulting N-oxime using sodium borohydride. The overall yield is around 75%, and the reaction is selective, producing the desired amine with high purity.

What industries use 3-Methoxy-5-methylpyrazin-2-amine (CAS: 89464-87-9)?

3-Methoxy-5-methylpyrazin-2-amine (CAS: 89464-87-9) is used in the pharmaceutical industry for the synthesis of certain drugs and intermediates. It also finds applications in the polymer industry for modifying properties of polymer materials. Additionally, it is used in the sensor industry for developing chemical sensors and in the semiconductor industry for specific chemical treatments.

What precautions should be taken when handling 3-Methoxy-5-methylpyrazin-2-amine (CAS: 89464-87-9)?

When handling 3-Methoxy-5-methylpyrazin-2-amine (CAS: 89464-87-9), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials and ensuring proper disposal. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.