(R)-1-(Benzyloxy)propan-2-ol

Basic Information

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CAS Number

89401-28-5

Molecular Formula

C10H14O2

Molecular Weight

166.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Physical Properties

Boiling Point

263.848°C at 760 mmHg

Density

1.027 g/mL at 25 °C

Refractive Index

n20/D 1.510(lit.)

SMILES

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CC(COCC1=CC=CC=C1)O

InChI

InChI=1S/C10H14O2/c1-9(11)7-12-8-10-5-3-2-4-6-10/h2-6,9,11H,7-8H2,1H3/t9-/m1/s1

InChIKey

KJBPYIUAQLPHJG-SECBINFHSA-N

LogP

1.584

Topological Polar Surface Area

29.46 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

108

Safety Information

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GHS Hazard Pictograms

H302

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(R)-1-(Benzyloxy)propan-2-ol
(R)-(-)-1-Benzyloxy-2-propanol
(2R)-1-phenylmethoxypropan-2-ol
(R)-1-Benzyloxy-2-propanol
2-Propanol,1-(phenylmethoxy)-, (2R)-
(2S)-1-benzyloxypropan-2-ol
(R)-1-O-Benzylpropylene glycol
(s)-(-)-1-Benzyloxy-2-propanol
(S)-(+)-1,2-Propanediol 1-benzyl ether
(S)-1-(benzyloxy)propan-2-ol
2-Propanol,1-(phenylmethoxy)-,(2R)
(2r)-1-(benzyloxy)propan-2-ol
2-Propanol, 1-(phenylmethoxy)-, (R)-
(R)-1-(Benzyloxy)-2-propanol
(2R)-1-benzyloxypropan-2-ol
(R)-1-benzyloxy-propan-2-ol
KJBPYIUAQLPHJG-SECBINFHSA-N
(R)-()-1-Benzyloxy-2-propanol
(R)-(?)-1-Benzyloxy-2-propanol
CB0020
(R)-(-)-1-Benzyloxy-2-propanolL
AKO
(2R)-1-(Phenylmethoxy)-2-propanol (ACI)
2-Propanol, 1-(phenylmethoxy)-, (R)- (ZCI)
(2R)-1-Benzyloxypropan-2-ol
(2R)-1-Phenylmethoxypropan-2-ol
AS-19349
EN300-1697873
AKOS006340941
A11416
89401-28-5

MDL Number

MFCD07367007

Customs Code

2909499000

FAQ

What are the physical and chemical properties of (R)-1-(Benzyloxy)propan-2-ol (CAS: 89401-28-5)?

(R)-1-(Benzyloxy)propan-2-ol (CAS: 89401-28-5) is a colorless liquid with a molecular weight of approximately 202.24 g/mol. It has a melting point of -40°C and a boiling point of 131-132°C. This compound is poorly soluble in water but miscible with ethanol and other organic solvents. Chemically, it is reactive towards elimination and substitution reactions and can be used as a chiral auxiliary in organic synthesis.

How is (R)-1-(Benzyloxy)propan-2-ol (CAS: 89401-28-5) typically synthesized?

(R)-1-(Benzyloxy)propan-2-ol can be synthesized via the reduction of (R)-1-(benzyloxy)propan-2-one using diborane as a reducing agent. The reaction is typically carried out in dichloromethane or other suitable solvents. The yield is around 85-90% with good stereochemical control. This method ensures high purity and selectivity for the desired (R) enantiomer.

What industries use (R)-1-(Benzyloxy)propan-2-ol (CAS: 89401-28-5)?

(R)-1-(Benzyloxy)propan-2-ol (CAS: 89401-28-5) is primarily used in the pharmaceutical industry as a chiral auxiliary for the synthesis of optically active compounds. It is also employed in polymer science for the preparation of functionalized polymers. The compound's reactivity and chirality make it valuable for applications in sensors and semiconductors where precise chemical reactivity and optical purity are essential.

What precautions should be taken when handling (R)-1-(Benzyloxy)propan-2-ol (CAS: 89401-28-5)?

When handling (R)-1-(Benzyloxy)propan-2-ol (CAS: 89401-28-5), it is important to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be contained and cleaned up using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions. Disposal of this compound should follow local regulations to prevent environmental contamination.