5-Cyclopropyl-2-pyridinamine

Basic Information

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CAS Number

893738-68-6

Molecular Formula

C8H10N2

Molecular Weight

134.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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C1CC1C2=CN=C(C=C2)N

InChI

InChI=1S/C8H10N2/c9-8-4-3-7(5-10-8)6-1-2-6/h3-6H,1-2H2,(H2,9,10)

InChIKey

BBYIRRCVJZYNIH-UHFFFAOYSA-N

LogP

1.5412000000000001

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

120

Synonyms & References

English

EN300-360730
5-cyclopropylpyridin-2-amine
DTXSID10629589
DS-6225
SY117327
BBYIRRCVJZYNIH-UHFFFAOYSA-N
FT-0755554
SCHEMBL1355472
J-517459
5-Cyclopropyl-pyridin-2-ylamine
A1-39448
AKOS004118818
SB75413
CS-W022369
893738-68-6
2-Amino-5-cyclopropylpyridine
MFCD06802676
5-Cyclopropylpyridin-2-amine
5-Cyclopropylpyridine-2-amine
2-Pyridinamine, 5-cyclopropyl-
AK129592
5-Cyclopropyl-2-pyridinamine (ACI)

MDL Number

MFCD06802676

FAQ

What are the physical and chemical properties of 5-Cyclopropyl-2-pyridinamine (CAS: 893738-68-6)?

5-Cyclopropyl-2-pyridinamine is a white crystalline solid with a molecular weight of approximately 141.17 g/mol. It has a solubility of about 20 mg/mL in water and is slightly soluble in ethanol. This compound is known for its reactivity, particularly towards nucleophilic substitution reactions.

How is 5-Cyclopropyl-2-pyridinamine (CAS: 893738-68-6) typically synthesized?

5-Cyclopropyl-2-pyridinamine is typically synthesized by the reaction of 2-pyridineboronic acid with cyclopropylboronic acid, followed by a Suzuki coupling reaction. This method provides a yield of around 80% with good selectivity. The reaction is catalyzed by Pd(PPh3)4 and requires a base such as sodium carbonate.

What industries use 5-Cyclopropyl-2-pyridinamine (CAS: 893738-68-6)?

5-Cyclopropyl-2-pyridinamine is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It is also explored in the polymer industry for its potential in developing novel polymers with unique properties. Additionally, it has applications in the semiconductor and sensor industries due to its electronic properties.

What precautions should be taken when handling 5-Cyclopropyl-2-pyridinamine (CAS: 893738-68-6)?

When handling 5-Cyclopropyl-2-pyridinamine, ensure proper personal protective equipment (PPE) is worn, including gloves, safety glasses, and a lab coat. Work should be conducted in a fume hood to avoid exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed handling procedures and safety information.