5-Cyclopropyl-2-pyridinamine(CAS: 893738-68-6)

5-Cyclopropyl-2-pyridinamine is a white crystalline solid with a molecular weight of approximately 141.17 g/mol. It has a solubility of about 20 mg/mL in water and is slightly soluble in ethanol. This compound is known for its reactivity, particularly towards nucleophilic substitution reactions.

5-Cyclopropyl-2-pyridinamine is typically synthesized by the reaction of 2-pyridineboronic acid with cyclopropylboronic acid, followed by a Suzuki coupling reaction. This method provides a yield of around 80% with good selectivity. The reaction is catalyzed by Pd(PPh3)4 and requires a base such as sodium carbonate.

5-Cyclopropyl-2-pyridinamine is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It is also explored in the polymer industry for its potential in developing novel polymers with unique properties. Additionally, it has applications in the semiconductor and sensor industries due to its electronic properties.

When handling 5-Cyclopropyl-2-pyridinamine, ensure proper personal protective equipment (PPE) is worn, including gloves, safety glasses, and a lab coat. Work should be conducted in a fume hood to avoid exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed handling procedures and safety information.