(3-Chloropyrazin-2-yl)methanol

Basic Information

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CAS Number

89283-32-9

Molecular Formula

C5H5ClN2O

Molecular Weight

144.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

256 ºC

Density

1.422

Flash Point

108 ºC

SMILES

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C1=CN=C(C(=N1)CO)Cl

InChI

InChI=1S/C5H5ClN2O/c6-5-4(3-9)7-1-2-8-5/h1-2,9H,3H2

InChIKey

NYTVRJQDIXLFAT-UHFFFAOYSA-N

LogP

0.6223000000000001

Topological Polar Surface Area

46.010000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(3-Chloropyrazin-2-yl)methanol
(3-Chloro-pyrazin-2-yl)-methanol
2-Pyrazinemethanol, 3-chloro-
3-Chloro-2-pyrazinemethanol
(3-chloranylpyrazin-2-yl)methanol
(3-chloro-2-pyrazinyl)methanol
(3-chloropyrazin-2-yl)-methanol
2-Chlor-3-pyrazylmethanol
QC-971
3-Chloro-2-(hydroxymethyl)pyrazine
(3-Chloropyrazin-2-yl);methanol
NYTVRJQDIXLFAT-UHFFFAOYSA-N
BCP23142
4741AC
FCH1120647
PB33021
SY023912
AX8160859
ST1120844
AB0079751
3-Chloro-2-pyrazinemethanol (ACI)
Pyrazinemethanol, 3-chloro- (7CI, 9CI)
(3-chloropyrazin-2-yl)methanol
CS-0053374
SCHEMBL400853
89283-32-9
AKOS015918973
MFCD11977628
DTXSID40653998

MDL Number

MFCD11977628

Customs Code

2933990090

FAQ

What are the physical and chemical properties of (3-Chloropyrazin-2-yl)methanol (CAS: 89283-32-9)?

(3-Chloropyrazin-2-yl)methanol is a colorless liquid with a molecular weight of approximately 156.02 g/mol. It has a density of about 1.14 g/cm³ and a boiling point of around 200°C. This compound is slightly soluble in water but miscible with common organic solvents. It is known to be reactive towards nucleophiles and can undergo substitution reactions. Proper storage should be at room temperature away from direct sunlight to maintain its stability.

How is (3-Chloropyrazin-2-yl)methanol (CAS: 89283-32-9) typically synthesized?

(3-Chloropyrazin-2-yl)methanol can be synthesized via a multistep process involving the preparation of 3-chloropyrazine, followed by its methylation. This is typically achieved through the reaction of 3-chloropyrazine with methyl iodide in the presence of a base like potassium carbonate. The yield and selectivity can be enhanced by optimizing reaction conditions such as temperature and solvent choice. This process requires careful handling of reactive intermediates and should be conducted under a fume hood.

What industries use (3-Chloropyrazin-2-yl)methanol (CAS: 89283-32-9)?

(3-Chloropyrazin-2-yl)methanol finds application in various industries, particularly in pharmaceuticals and research. It is used as a precursor in the synthesis of complex organic compounds and as a reagent in academic and industrial research. Its utility in the pharmaceutical industry is due to its potential as a building block for drug molecules. Additionally, it is explored in the development of new materials and sensors for its unique chemical properties.

What precautions should be taken when handling (3-Chloropyrazin-2-yl)methanol (CAS: 89283-32-9)?

When handling (3-Chloropyrazin-2-yl)methanol, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Due to its reactivity, this compound should be stored in a cool, dry place away from direct sunlight and flammable materials. Fume hoods should be used during handling to minimize exposure. In case of a spill, it is important to follow standard laboratory safety procedures, including the use of appropriate absorbents and neutralizing agents. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.