Bafilomycin A1

Basic Information

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CAS Number

88899-55-2

Molecular Formula

C35H58O9

Molecular Weight

622.84 g/mol

EINECS

621-324-4

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

>106°C (dec.)

Boiling Point

582.86°C (rough estimate)

Density

1.0594 (rough estimate)

Water Solubility

Soluble in methanol, ethanol, acetone and chloroform. Insoluble in water.

Flash Point

87℃

Refractive Index

1.5000 (estimate)

SMILES

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CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C

InChI

InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChIKey

XDHNQDDQEHDUTM-JQWOJBOSSA-N

LogP

4.692700000000004

pKa

12.66±0.70(Predicted)

Topological Polar Surface Area

134.91000000000003 Å²

Hydrogen Bond Donor/Acceptor

4 / 9

Complexity

1060

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1(b) Class 6.1(b)

Stability

Storage in solution in DMSO at -20°C for up to 3 months.

Sensitiveness

Sensitive to heat and light

Synonyms & References

English

Bafilomycin A1 Bafilomycin A1 from Streptomyces griseus
Bafilomycin A1(Baf-A1)
Bafilomycin A1, 95%, from Streptomyces griseus
CS-1163
Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem
BAFILOMYCIN A1
BAFILOMYCIN A1, STREPTOMYCES GRISEUS
Bafilomycin A1 from Streptomycesgriseus, 10 ug
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5
BafilomycinA1fromStreptomycesgriseus
21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin
Bafilomycin A1 (NSC 381866)
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-Methyl-6-(1-Methylethyl)-2H-pyran-2-yl]butyl]-3
bafilomycin
Bafilomycin A1 from Streptomyces griseus
Bafilomycin A
(-)-Bafilomycin A1
Bafilomycin A1
HB1125
DB06733
NSC381866
DTXCID801473810
CHEMBL290814
BSPBio_001470
SCHEMBL13775181
NCGC00163426-02
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl]-3-hydroxypentan-2-yl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
XDHNQDDQEHDUTM-JQWOJBOSSA-N
C35H58O9
HMS3402J12
BafA1

MDL Number

MFCD06795130

EC Number

621-324-4

Customs Code

29419090

FAQ

What is Bafilomycin A1 (CAS: 88899-55-2)?

Bafilomycin A1 is a macrocyclic antibiotic produced by Streptomyces griseus. It is known for its potent inhibitory activity towards vacuolar-type H+-ATPase (V-ATPase), a key enzyme in the endosomal and lysosomal compartments. It has a chemical formula of C71H103N17O21.

What are the main uses of Bafilomycin A1 (CAS: 88899-55-2)?

Bafilomycin A1 is primarily used as an antifungal and anticancer agent. It is also employed in research to study cellular processes involving the endosomal and lysosomal systems. Its applications include treating fungal infections and certain types of cancer, particularly in combination therapies.

Is Bafilomycin A1 (CAS: 88899-55-2) safe?

Bafilomycin A1 is generally considered safe when used under medical supervision. However, it can cause toxic effects, including liver toxicity and renal impairment, particularly at high doses. Protective measures include avoiding contact with skin and eyes and using appropriate protective clothing.

How should Bafilomycin A1 (CAS: 88899-55-2) be stored?

Bafilomycin A1 should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept at a temperature not exceeding 25°C. The compound should be protected from moisture and stored in a tightly closed container to maintain its stability and prevent degradation.