Bafilomycin A1(CAS: 88899-55-2)

Bafilomycin A1 is a macrocyclic antibiotic produced by Streptomyces griseus. It is known for its potent inhibitory activity towards vacuolar-type H+-ATPase (V-ATPase), a key enzyme in the endosomal and lysosomal compartments. It has a chemical formula of C71H103N17O21.

Bafilomycin A1 is primarily used as an antifungal and anticancer agent. It is also employed in research to study cellular processes involving the endosomal and lysosomal systems. Its applications include treating fungal infections and certain types of cancer, particularly in combination therapies.

Bafilomycin A1 is generally considered safe when used under medical supervision. However, it can cause toxic effects, including liver toxicity and renal impairment, particularly at high doses. Protective measures include avoiding contact with skin and eyes and using appropriate protective clothing.

Bafilomycin A1 should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept at a temperature not exceeding 25°C. The compound should be protected from moisture and stored in a tightly closed container to maintain its stability and prevent degradation.