5-Iodo-3-(trifluoromethyl)pyridin-2-OL

Basic Information

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CAS Number

887707-23-5

Molecular Formula

C6H3F3INO

Molecular Weight

288.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

145-147℃

Boiling Point

249.186 ℃ at 760 mmHg

Density

2.11

Flash Point

105℃

SMILES

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C1=C(C(=O)NC=C1I)C(F)(F)F

InChI

InChI=1S/C6H3F3INO/c7-6(8,9)4-1-3(10)2-11-5(4)12/h1-2H,(H,11,12)

InChIKey

ACMILMILHHLANU-UHFFFAOYSA-N

LogP

1.9983

Topological Polar Surface Area

32.86 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

279

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

5-Iodo-3-(trifluoromethyl)pyridin-2(1H)-one
5-Iodo-3-(trifluoromethyl)-2(1H)-pyridinone
2-Hydroxy-5-Iodo-3-(trifluoromethyl)pyridine
5-iodo-3-(trifluoromethyl)-1H-pyridin-2-one
5-iodo-3-(trifluoromethyl)pyridin-2-ol
5-Iodo-3-(trifluoromethyl)-2(1H)-pyridinone (ACI)
2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine
5-Iodo-3-(trifluoromethyl)pyridin-2-ol
5-iodo-3-trifluoromethyl-2-pyridinol
SCHEMBL1701624
DB-026959
RB1085
5-IODO-3-(TRIFLUOROMETHYL)PYRIDIN-2-OL
2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine
EN300-104068
MFCD12024303
AKOS015853761
5-Iodo-3-(Trifluoromethyl)-2(1H)-Pyridinone
MB07299
5-IODO-3-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDIN-2-ONE
AKOS022171436
2-HYDROXY-3-TRIFLUOROMETHYL-5-IODO-PYRIDINE
AC-22597
DTXSID20468007
5-Iodo-2-hydroxy-3-(trifluoromethyl)pyridine
887707-23-5
2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine;5-Iodo-2-hydroxy-3-(trifluoromethyl)pyridine
SY035124
BCP31441
2-hydroxy-5-iodo-3-(trifluoromethyl)pyridine
EK-0716

MDL Number

MFCD12024303

FAQ

What are the physical and chemical properties of 5-Iodo-3-(trifluoromethyl)pyridin-2-OL (CAS: 887707-23-5)?

5-Iodo-3-(trifluoromethyl)pyridin-2-ol is a crystalline compound with a molecular weight of approximately 330.01 g/mol. It exhibits low water solubility and is generally poor in organic solvents. The compound is highly reactive due to the presence of the iodo and trifluoromethyl groups, which can participate in nucleophilic and electrophilic reactions.

How is 5-Iodo-3-(trifluoromethyl)pyridin-2-ol (CAS: 887707-23-5) typically synthesized?

5-Iodo-3-(trifluoromethyl)pyridin-2-ol is typically synthesized through a multi-step process involving the bromination of 3-(trifluoromethyl)pyridin-2-ol followed by iodination. Common catalysts include palladium complexes, and high yields can be achieved with appropriate reaction conditions and purification techniques.

What industries use 5-Iodo-3-(trifluoromethyl)pyridin-2-ol (CAS: 887707-23-5)?

5-Iodo-3-(trifluoromethyl)pyridin-2-ol is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in the polymer industry for cross-linking applications and in the sensor industry for its unique reactivity with specific analytes.

What precautions should be taken when handling 5-Iodo-3-(trifluoromethyl)pyridin-2-ol (CAS: 887707-23-5)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 5-Iodo-3-(trifluoromethyl)pyridin-2-ol. Work should be conducted in a fume hood to minimize exposure. Spills should be carefully cleaned up using appropriate materials and procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information.