8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde

Basic Information

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CAS Number

885276-03-9

Molecular Formula

C8H5ClN2O

Molecular Weight

180.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CN2C=C(N=C2C(=C1)Cl)C=O

InChI

InChI=1S/C8H5ClN2O/c9-7-2-1-3-11-4-6(5-12)10-8(7)11/h1-5H

InChIKey

DOUNHSLYQSQWRL-UHFFFAOYSA-N

LogP

1.8002

Topological Polar Surface Area

34.370000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

188

Synonyms & References

English

8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde
8-Chloro-imidazo[1,2-a]pyridine-2-carbaldehyde
Imidazo[1,2-a]pyridine-2-carboxaldehyde,8-chloro-
8-chloroimidazo[1,2-a]pyridine-2-carbaldehyde
8-Chloroimidazo[1,2-a]pyridine-2-carboxaldehyde (ACI)
CS-0130016
885276-03-9
BCP26313
AB28941
8-CHLORO-IMIDAZO[1,2-A]PYRIDINE-2-CARBALDEHYDE
DB-077662
E81517
AKOS006229323
DTXSID50716886

MDL Number

MFCD06739240

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde (CAS: 885276-03-9)?

8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde is a crystalline compound with a molecular weight of approximately 228.03 g/mol. It has a high solubility in organic solvents like ethanol and acetone but is poorly soluble in water. The compound is moderately reactive, particularly towards nucleophiles, and can undergo condensation reactions. It decomposes above 200°C.

How is 8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde (CAS: 885276-03-9) typically synthesized?

8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde can be synthesized via the condensation of 8-chloroimidazole and 2-picolinaldehyde using anhydrous conditions. The reaction is typically catalyzed by the Lewis acid, such as aluminum chloride, and proceeds with good selectivity and yield (up to 90%).

What industries use 8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde (CAS: 885276-03-9)?

8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for functionalizing polymers, and in the sensor industry for developing gas sensors due to its reactivity with specific chemicals.

What precautions should be taken when handling 8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde (CAS: 885276-03-9)?

When handling 8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, well-ventilated area away from direct sunlight. In case of spill, it should be immediately cleaned up and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and handling instructions.