8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde(CAS: 885276-03-9)

8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde is a crystalline compound with a molecular weight of approximately 228.03 g/mol. It has a high solubility in organic solvents like ethanol and acetone but is poorly soluble in water. The compound is moderately reactive, particularly towards nucleophiles, and can undergo condensation reactions. It decomposes above 200°C.

8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde can be synthesized via the condensation of 8-chloroimidazole and 2-picolinaldehyde using anhydrous conditions. The reaction is typically catalyzed by the Lewis acid, such as aluminum chloride, and proceeds with good selectivity and yield (up to 90%).

8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for functionalizing polymers, and in the sensor industry for developing gas sensors due to its reactivity with specific chemicals.

When handling 8-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, well-ventilated area away from direct sunlight. In case of spill, it should be immediately cleaned up and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and handling instructions.