Axitinib Impurity 1

Basic Information

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CAS Number

885126-40-9

Molecular Formula

C22H18N4OS

Molecular Weight

386.48 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

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CNC(=O)c1ccccc1Sc2ccc3c(c2)[nH]nc3/C=C\c4ccccn4

InChI

InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9-

InChIKey

RITAVMQDGBJQJZ-XFXZXTDPSA-N

LogP

4.6391000000000036

Topological Polar Surface Area

70.67 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Synonyms & References

English

Benzamide,N-methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-
Axitinib Impurity 15
N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide (ACI)
(Z)-N-methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

FAQ

What regulatory guidelines apply to Axitinib Impurity 1 (CAS: 885126-40-9)?

The regulation of Axitinib Impurity 1 (CAS: 885126-40-9) is guided by various regulatory bodies such as REACH in the EU, the EPA in the USA, and the FDA. These require strict adherence to safety data sheets, hazard communication standards, and proper labeling. Additionally, this impurity must comply with Good Manufacturing Practices (GMP) and International Council for Harmonization (ICH) guidelines to ensure its quality and safety in pharmaceutical manufacturing and research.

Are there alternatives to Axitinib Impurity 1 (CAS: 885126-40-9) in synthesis?

Alternative reagents to Axitinib Impurity 1 (CAS: 885126-40-9) may include similar functional group equivalents or analogs such as various tyrosine kinase inhibitors. Isomers and structural homologues can also be considered. These alternatives can offer different reactivity profiles or synthetic pathways, but their selection should be based on the specific requirements of the synthesis and the analytical tools available for their detection.

What is the market or research trend for Axitinib Impurity 1 (CAS: 885126-40-9)?

The market trend for Axitinib Impurity 1 (CAS: 885126-40-9) reflects the broader research interest in tyrosine kinase inhibitors. With ongoing advancements in cancer therapy and personalized medicine, there is an increasing focus on understanding and controlling impurities in drug formulations. Research trends aim to improve the purity and safety of axitinib, the parent compound, and its related impurities like Axitinib Impurity 1, to enhance therapeutic efficacy and patient safety.

How should waste containing Axitinib Impurity 1 (CAS: 885126-40-9) be handled?

Waste containing Axitinib Impurity 1 (CAS: 885126-40-9) should be managed carefully to ensure environmental safety. Collection should be done in sealed containers and incineration should be performed in an approved facility. For non-incinerable waste, professional waste disposal services should be utilized. Proper labeling and documentation are essential to comply with environmental protection regulations. Safe handling and disposal practices should follow guidelines set by local authorities and international standards such as the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).