3-Bromo-5-fluoro-2-methoxypyridine

Basic Information

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CAS Number

884494-81-9

Molecular Formula

C6H5BrFNO

Molecular Weight

206.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

188.3℃ at 760 mmHg

Density

1.621

Flash Point

67.715°C

Refractive Index

1.5390 to 1.5430

SMILES

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COC1=C(C=C(C=N1)F)Br

InChI

InChI=1S/C6H5BrFNO/c1-10-6-5(7)2-4(8)3-9-6/h2-3H,1H3

InChIKey

HSWCOAGQYSBFAK-UHFFFAOYSA-N

LogP

1.9917999999999998

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

114

Safety Information

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Hazard Statement

H227 Combustible liquid
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Sensitiveness

Light Sensitive

Synonyms & References

English

3-Bromo-5-fluoro-2-methoxypyridine
2-methoxy-3-bromo-5-fluoropyridine
2-Methoxy-3-Methyl-5-nitropyridine
3-bromo-5-fluoro-2-methoxy-pyridine
Pyridine,3-bromo-5-fluoro-2-methoxy-
PYRIDINE, 3-BROMO-5-FLUORO-2-METHOXY-
3-Bromo-5-fluoro-2-methoxypyrdine
PubChem1175
HSWCOAGQYSBFAK-UHFFFAOYSA-N
BCP23394
PC49160
AS04795
TRA0050951
LF10384
FCH1328167
C
3-Bromo-5-fluoro-2-methoxypyridine (ACI)
B5134
SCHEMBL933336
CS-W003209
Q-103373
EN300-1697317
DTXCID60604967
3-bromo-5-fluoro-2-methoxypyridine
DTXSID30654217
5-Fluoro-3-bromo-2-methoxypyridine
DB-024953
AC-33410
2-METHOXY-3-BROMO-5-FLUOROPYRIDINE
AKOS005145878
MFCD04972397

MDL Number

MFCD04972397

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9)?

3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9) is a crystalline solid with a molecular weight of approximately 222.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, especially with nucleophiles. It is used in the synthesis of various pharmaceuticals and organic compounds due to its functional groups.

How is 3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9) typically synthesized?

3-Bromo-5-fluoro-2-methoxypyridine is typically synthesized via bromination of 5-fluoro-2-methoxypyridine followed by amination. The process involves the use of N-bromosuccinimide (NBS) as a brominating agent and basic conditions. The reaction is carried out in an inert atmosphere to prevent side reactions. Yield is generally around 70-80%, and the product can be isolated by recrystallization.

What industries use 3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9)?

3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9) is primarily used in the pharmaceutical and chemical industries. It serves as an intermediate in the synthesis of active pharmaceutical ingredients (APIs) and other organic compounds. Its use in the polymer and semiconductor industries is also reported, where it can be utilized for specific functionalization and modification purposes.

What precautions should be taken when handling 3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9)?

When handling 3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure the use of a fume hood during operations to minimize inhalation risks. Spills should be handled with caution; sweep up and dispose of according to local chemical waste regulations. For more detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS).