3-Bromo-5-fluoro-2-methoxypyridine(CAS: 884494-81-9)

3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9) is a crystalline solid with a molecular weight of approximately 222.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, especially with nucleophiles. It is used in the synthesis of various pharmaceuticals and organic compounds due to its functional groups.

3-Bromo-5-fluoro-2-methoxypyridine is typically synthesized via bromination of 5-fluoro-2-methoxypyridine followed by amination. The process involves the use of N-bromosuccinimide (NBS) as a brominating agent and basic conditions. The reaction is carried out in an inert atmosphere to prevent side reactions. Yield is generally around 70-80%, and the product can be isolated by recrystallization.

3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9) is primarily used in the pharmaceutical and chemical industries. It serves as an intermediate in the synthesis of active pharmaceutical ingredients (APIs) and other organic compounds. Its use in the polymer and semiconductor industries is also reported, where it can be utilized for specific functionalization and modification purposes.

When handling 3-Bromo-5-fluoro-2-methoxypyridine (CAS: 884494-81-9), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure the use of a fume hood during operations to minimize inhalation risks. Spills should be handled with caution; sweep up and dispose of according to local chemical waste regulations. For more detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS).