4-Chloro-5-methylpicolinic acid

Basic Information

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CAS Number

882679-14-3

Molecular Formula

C7H6ClNO2

Molecular Weight

171.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Density

1.390±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

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CC1=CN=C(C=C1Cl)C(=O)O

InChI

InChI=1S/C7H6ClNO2/c1-4-3-9-6(7(10)11)2-5(4)8/h2-3H,1H3,(H,10,11)

InChIKey

IIYOXHJTMDXVMM-UHFFFAOYSA-N

LogP

1.74162

Topological Polar Surface Area

50.19 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

163

Synonyms & References

English

4-Chloro-5-methyl-2-pyridinecarboxylic acid
4-Chloro-5-methylpicolinic acid
4-chloro-5-methylpyridine-2-carboxylic acid
IIYOXHJTMDXVMM-UHFFFAOYSA-N
FCH1169433
AB65446
AK151401
AX8273718
2-Pyridinecarboxylic acid, 4-chloro-5-methyl-
4-Chloro-5-methyl-2-pyridinecarboxylic acid (ACI)
4-CHLORO-5-METHYLPYRIDINE-2-CARBOXYLIC ACID
CS-0186989
882679-14-3
4-CHLORO-5-METHYLPICOLINIC ACID
AS-50179
SCHEMBL935259
AKOS005259476
Z1255439777
4-CHLORO-5-METHYLPICOLINICACID
MFCD12400883
O11218
DTXSID40702298
SY260457
EN300-130090

MDL Number

MFCD12400883

FAQ

What are the physical and chemical properties of 4-Chloro-5-methylpicolinic acid (CAS: 882679-14-3)?

4-Chloro-5-methylpicolinic acid is a compound with a crystalline form. Its molecular weight is approximately 205.57 g/mol. It is slightly soluble in water and ethanol. The acid is reactive towards bases and can undergo substitution reactions. It has a melting point of 188-190°C and a pKa of around 2.3.

How is 4-Chloro-5-methylpicolinic acid (CAS: 882679-14-3) typically synthesized?

4-Chloro-5-methylpicolinic acid is typically synthesized via the chlorination of 5-methylpicolinic acid followed by protonation. Common methods include Friedel-Crafts alkylation followed by halogenation. The reaction is catalyzed by Lewis acids and typically has a yield of about 85-90%.

What industries use 4-Chloro-5-methylpicolinic acid (CAS: 882679-14-3)?

4-Chloro-5-methylpicolinic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry as a monomer for the development of functional polymers. Additionally, it is employed in the sensor industry for the detection of specific compounds and in semiconductor manufacturing as a precursor.

What precautions should be taken when handling 4-Chloro-5-methylpicolinic acid (CAS: 882679-14-3)?

When handling 4-Chloro-5-methylpicolinic acid, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn. It should be stored in a fume hood to minimize exposure to fumes. Spills should be cleaned up with a suitable absorbent material and disposed of according to local regulations. Safety data sheets (SDS) should be consulted for detailed information on handling and storage.