4-Chloro-5-methylpicolinic acid(CAS: 882679-14-3)

4-Chloro-5-methylpicolinic acid is a compound with a crystalline form. Its molecular weight is approximately 205.57 g/mol. It is slightly soluble in water and ethanol. The acid is reactive towards bases and can undergo substitution reactions. It has a melting point of 188-190°C and a pKa of around 2.3.

4-Chloro-5-methylpicolinic acid is typically synthesized via the chlorination of 5-methylpicolinic acid followed by protonation. Common methods include Friedel-Crafts alkylation followed by halogenation. The reaction is catalyzed by Lewis acids and typically has a yield of about 85-90%.

4-Chloro-5-methylpicolinic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry as a monomer for the development of functional polymers. Additionally, it is employed in the sensor industry for the detection of specific compounds and in semiconductor manufacturing as a precursor.

When handling 4-Chloro-5-methylpicolinic acid, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn. It should be stored in a fume hood to minimize exposure to fumes. Spills should be cleaned up with a suitable absorbent material and disposed of according to local regulations. Safety data sheets (SDS) should be consulted for detailed information on handling and storage.