2-Chloro-5-fluoro-4-methylpyridine

Basic Information

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CAS Number

881891-83-4

Molecular Formula

C6H5ClFN

Molecular Weight

145.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

183℃ at 760 mmHg

Density

1.264

Flash Point

64℃

SMILES

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CC1=CC(=NC=C1F)Cl

InChI

InChI=1S/C6H5ClFN/c1-4-2-6(7)9-3-5(4)8/h2-3H,1H3

InChIKey

HWDRAVIZSYVICK-UHFFFAOYSA-N

LogP

2.1825200000000002

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

99.1

Synonyms & References

English

2-Chloro-5-fluoro-4-methylpyridine
2-Chloro-5-fluoro-4-methyl-pyridine
2-chloro-5-fluoro-4-picoline
Pyridine,2-chloro-5-fluoro-4-methyl-
PubChem10460
KSC659I7R
HWDRAVIZSYVICK-UHFFFAOYSA-N
SBB086442
FCH922982
PC8383
VP13667
AF10137
SY030542
ST2409856
AX8035248
AB0027226
2-Chloro-5-fluoro-4-methylpyridine (ACI)
881891-83-4
CS-W003672
SCHEMBL4924144
MFCD09864695
DB-025043
J-508820
AKOS006346314
AC-24931
DTXSID40650503
DS-11948

MDL Number

MFCD09864695

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4)?

2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4) is a crystalline solid with a molecular weight of approximately 195.57 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is also prone to hydrolysis under basic conditions.

How is 2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4) typically synthesized?

2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4) can be synthesized via the Friedel-Crafts alkylation of 2-chloro-5-fluoropyridine with methyl chloride. The reaction is typically performed in the presence of a Lewis acid catalyst, such as aluminum chloride, at elevated temperatures. The yield is generally high, and the method is selective.

What industries use 2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4)?

2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4) is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the production of organic semiconductors and as a precursor in the synthesis of other chemical intermediates. Its applications in polymers and sensors are less common but have been explored.

What precautions should be taken when handling 2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4)?

When handling 2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4), proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from moisture and heat sources. In case of a spill, it should be handled with appropriate safety measures, and the Material Safety Data Sheet (MSDS) should be consulted for detailed instructions.