2-Chloro-5-fluoro-4-methylpyridine(CAS: 881891-83-4)

2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4) is a crystalline solid with a molecular weight of approximately 195.57 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is also prone to hydrolysis under basic conditions.

2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4) can be synthesized via the Friedel-Crafts alkylation of 2-chloro-5-fluoropyridine with methyl chloride. The reaction is typically performed in the presence of a Lewis acid catalyst, such as aluminum chloride, at elevated temperatures. The yield is generally high, and the method is selective.

2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4) is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the production of organic semiconductors and as a precursor in the synthesis of other chemical intermediates. Its applications in polymers and sensors are less common but have been explored.

When handling 2-Chloro-5-fluoro-4-methylpyridine (CAS: 881891-83-4), proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from moisture and heat sources. In case of a spill, it should be handled with appropriate safety measures, and the Material Safety Data Sheet (MSDS) should be consulted for detailed instructions.