5-Bromo-2-hydroxymethylpyridine

Basic Information

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CAS Number

88139-91-7

Molecular Formula

C6H6BrNO

Molecular Weight

188.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Solid

Melting Point

59.0 to 63.0 deg-C

Boiling Point

120°C/0.06mmHg

Flash Point

0℃

SMILES

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C1=CC(=NC=C1Br)CO

InChI

InChI=1S/C6H6BrNO/c7-5-1-2-6(4-9)8-3-5/h1-3,9H,4H2

InChIKey

RUCZFWMEACWFER-UHFFFAOYSA-N

LogP

1.3363999999999998

Topological Polar Surface Area

33.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

89.1

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

5-Bromo-2-hydroxymethylpyridine
(5-Bromopyrid-2-yl)methanol
2-Hydroxymethyl-5-bromopyridine
5-Bromo-2-(hydroxymethyl)pyridine
5-Bromo-2-pyridinemethanol
(5-BROMO-PYRIDIN-2-YL)-METHANOL
(5-bromopyridin-2-yl)methanol
2-PYRIDINEMETHANOL, 5-BROMO-
5-BROMOPYRIDINE-2-METHANOL
(5-bromo-2-pyridyl)methan-1-ol
(5-Bromo-pyridin-2-yl)methanol (5-Bromo-2-hydroxymethylpyridine)
(5-bromo-2-pyridyl)methanol
zlchem 391
PubChem7710
PubChem12387
5-bromo-2-pyridine methanol
KSC49
5-Bromo-2-pyridinemethanol (ACI)
(5-Bromo-2-pyridyl)methanol
(5-Bromopyridin-2-yl)methanol
W-204002
AKOS005255303
DTXSID40409417
H5AM7UXN25
88139-91-7
STL554653
(5-bromopyridin-2-yl)-methanol
UNII-H5AM7UXN25
(5-Bromo-2-pyridyl)methanol;5-Bromo-2-hydroxymethylpyridine
SY002137
5-bromo-2-hydroxymethylpyridine, AldrichCPR

MDL Number

MFCD04035597

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-Bromo-2-hydroxymethylpyridine (CAS: 88139-91-7)?

5-Bromo-2-hydroxymethylpyridine (CAS: 88139-91-7) is a crystalline solid with a molecular weight of approximately 212.03 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. This compound exhibits basic properties due to the presence of the hydroxymethyl group. It is moderately reactive, particularly towards nucleophiles and electrophiles, and is often used in organic synthesis due to its functional groups.

How is 5-Bromo-2-hydroxymethylpyridine (CAS: 88139-91-7) typically synthesized?

5-Bromo-2-hydroxymethylpyridine is commonly synthesized via the bromination of 2-hydroxymethylpyridine. This process involves the reaction of 2-hydroxymethylpyridine with bromine in the presence of a suitable catalyst, such as iron(III) bromide. The reaction yields a high yield of 5-bromo-2-hydroxymethylpyridine with good selectivity, making it a versatile intermediate in organic synthesis.

What industries use 5-Bromo-2-hydroxymethylpyridine (CAS: 88139-91-7)?

5-Bromo-2-hydroxymethylpyridine (CAS: 88139-91-7) is primarily used in the pharmaceutical and chemical industries as a versatile intermediate. It finds applications in the synthesis of various organic compounds, particularly in the development of new drugs and materials. Its use in the polymer and semiconductor industries is also growing, where it serves as a precursor for functional materials.

What precautions should be taken when handling 5-Bromo-2-hydroxymethylpyridine (CAS: 88139-91-7)?

When handling 5-Bromo-2-hydroxymethylpyridine (CAS: 88139-91-7), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and lab coats. This compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up carefully using appropriate absorbents. Always consult the Material Safety Data Sheet (MSDS) for detailed handling and disposal instructions to ensure safety in the laboratory setting.