N-(3,4-Dimethoxyphenyl)acetamide

Basic Information

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CAS Number

881-70-9

Molecular Formula

C10H13NO3

Molecular Weight

195.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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CC(=O)NC1=CC(=C(C=C1)OC)OC

InChI

InChI=1S/C10H13NO3/c1-7(12)11-8-4-5-9(13-2)10(6-8)14-3/h4-6H,1-3H3,(H,11,12)

InChIKey

DZPYVOWPTBVRJR-UHFFFAOYSA-N

LogP

1.6621999999999997

Topological Polar Surface Area

47.56 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

196

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

F0239-0753
DTXSID80288223
FT-0681968
MFCD00026126
881-70-9
N-acetyl-4-aminoveratrole
Acetamide, N-(3,4-dimethoxyphenyl)-
FE-0764
N-(3,4-dimethoxyphenyl)-acetamide
4-acetamidoveratrole
J-522985
N-(3,4-Dimethoxyphenyl)acetamide #
NS00116164
L10168
NSC-54785
SCHEMBL1851780
AKOS000447186
NSC54785
CS-0149206
N-(3,4-Dimethoxyphenyl)acetamide
Z30849291
2,2-dimethoxy-N-phenylacetamide
3',4'-dimethoxyacetanilide
acetic acid-(3,4-dimethoxy-anilide)
dimethoxyphenylacetamide
Essigsaeure-(3,4-dimethoxy-anilid)
N-acetyl-3,4-dimethoxyaniline

MDL Number

MFCD00026126

Customs Code

2924299090

FAQ

What are the physical and chemical properties of N-(3,4-Dimethoxyphenyl)acetamide (CAS: 881-70-9)?

N-(3,4-Dimethoxyphenyl)acetamide (CAS: 881-70-9) is a white to off-white crystalline solid with a molecular weight of approximately 218.17 g/mol. It has a pKa of around 10.2. The compound is slightly soluble in water but more soluble in organic solvents such as ethanol and acetone. It is chemically stable but can react with strong bases and acids to form amine and carboxylic acid derivatives. It is also known to undergo hydrolysis under basic conditions.

How is N-(3,4-Dimethoxyphenyl)acetamide (CAS: 881-70-9) typically synthesized?

N-(3,4-Dimethoxyphenyl)acetamide (CAS: 881-70-9) can be synthesized by the reaction of 3,4-dimethoxybenzoic acid with acetamide. The synthesis typically involves the heating of 3,4-dimethoxybenzoic acid with acetamide in the presence of a base like sodium hydroxide. This reaction proceeds with good selectivity and yield, and it is often performed under mild conditions to avoid side reactions.

What industries use N-(3,4-Dimethoxyphenyl)acetamide (CAS: 881-70-9)?

N-(3,4-Dimethoxyphenyl)acetamide (CAS: 881-70-9) is predominantly used in the pharmaceutical industry for the synthesis of various pharmaceuticals. It is also utilized in the polymer industry for functionalizing polymers and in the sensor industry for developing chemical sensors. Additionally, it has applications in the semiconductor industry for its use in spin-on-glass (SOR) applications.

What precautions should be taken when handling N-(3,4-Dimethoxyphenyl)acetamide (CAS: 881-70-9)?

When handling N-(3,4-Dimethoxyphenyl)acetamide (CAS: 881-70-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound is not highly reactive but should be stored in a well-ventilated area to prevent the accumulation of vapors. In case of a spill, it should be handled in a fume hood, and the spill should be cleaned up according to standard safety protocols. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.