4-Chloro-3-(2-pyridinyl)aniline

Basic Information

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CAS Number

879088-41-2

Molecular Formula

C11H9ClN2

Molecular Weight

204.66 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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NC1=CC=C(Cl)C(C2=NC=CC=C2)=C1

InChI

InChI=1S/C11H9ClN2/c12-10-5-4-8(13)7-9(10)11-3-1-2-6-14-11/h1-7H,13H2

InChIKey

QWVLHTCIAZPQAY-UHFFFAOYSA-N

LogP

2.9842000000000013

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

4-chloro-3-(pyridin-2-yl)benzenamine
4-chloro-3-(2-pyridinyl)Benzenamine
4-chloro-3-(pyridin-2-yl)aniline
4-chloro-3-pyridin-2-ylaniline
4-Chloro-3-(2-pyridinyl)benzenamine (ACI)
4-Chloro-3-(2-pyridyl)aniline

MDL Number

MFCD12024455

FAQ

What are the physical and chemical properties of 4-Chloro-3-(2-pyridinyl)aniline (CAS: 879088-41-2)?

4-Chloro-3-(2-pyridinyl)aniline is a crystalline compound with a molecular weight of approximately 227.58 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound exhibits basic properties due to its amine group and can react with acids to form salts. It is moderately stable but can undergo photodegradation under strong light conditions.

How is 4-Chloro-3-(2-pyridinyl)aniline (CAS: 879088-41-2) typically synthesized?

4-Chloro-3-(2-pyridinyl)aniline is typically synthesized via a multistep process involving the reaction of 2-chloropyridine with aniline. This reaction is catalyzed by a Lewis acid such as aluminum chloride, leading to good yield and selectivity. The process requires careful temperature control and may involve the use of solvents like dichloromethane.

What industries use 4-Chloro-3-(2-pyridinyl)aniline (CAS: 879088-41-2)?

4-Chloro-3-(2-pyridinyl)aniline is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of certain drugs. It is also utilized in the production of dyes and pigments, and in some cases, as a precursor for the development of sensors and electronic materials.

What precautions should be taken when handling 4-Chloro-3-(2-pyridinyl)aniline (CAS: 879088-41-2)?

Proper handling of 4-Chloro-3-(2-pyridinyl)aniline requires the use of personal protective equipment (PPE) such as gloves, safety goggles, and lab coats. Work should be conducted in a well-ventilated area or a fume hood. Spills should be immediately contained and managed according to the Material Safety Data Sheet (MSDS). Always follow laboratory safety protocols and ensure proper storage in a cool, dry place away from direct sunlight.