N-(2-Phenylethyl)acetamide

Basic Information

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CAS Number

877-95-2

Molecular Formula

C10H13NO

Molecular Weight

163.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

51.0 to 55.0 deg-C

Boiling Point

154°C/2mmHg

Density

1.012

Flash Point

204 °C

Refractive Index

1.5400 (estimate)

Vapor Pressure

0.0±0.8 mmHg at 25°C

SMILES

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CC(=O)NCCc1ccccc1

InChI

InChI=1S/C10H13NO/c1-9(12)11-8-7-10-5-3-2-4-6-10/h2-6H,7-8H2,1H3,(H,11,12)

InChIKey

MODKMHXGCGKTLE-UHFFFAOYSA-N

LogP

1.3652000000000002

Topological Polar Surface Area

29.1 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

139

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

N-Phenethylacetamide
N-(2-Phenylethyl)acetamide
Acetamide,N-(2-phenylethyl)-
N-ACETYL-2-PHENYLETHYLAMINE
N-(2-Phenethyl)acetamide
N-(beta-Phenylethyl)acetamide
N-2-Phenethylacetamide
N-Acetylphenethylamine
NSC 7177
Acetamide, N-(2-phenylethyl)-
N-(Phenethyl)acetamide
N-Acetylphenylethylamine
N-beta-Phenylethylacetamide
Acetamide, N-phenethyl-
N-phenethyl-acetamide
N-(2-phenylethyl)-acetamide
2JXY218SZI
MODKMHXGCGKTLE-UHFFFAOYSA-N
Acetamide, N-phenethyl- (6CI,7CI,8CI)
acet
N-Acetyl-2-phenylethylamine
Acetamide, N-phenethyl- (6CI, 7CI, 8CI)
N-(2-Phenylethyl)acetamide (ACI)
Acetamide, N-(2-phenylethyl)
N-(β-Phenylethyl)acetamide

MDL Number

MFCD00026177

Customs Code

2924299090

FAQ

What are the physical and chemical properties of N-(2-Phenylethyl)acetamide (CAS: 877-95-2)?

N-(2-Phenylethyl)acetamide (CAS: 877-95-2) is a white crystalline solid with a molecular weight of 168.24 g/mol. It has a pKa of 15.5 and is slightly soluble in water. It is reactive towards nucleophiles and can undergo nucleophilic substitution reactions. It is also soluble in common organic solvents such as ethanol and acetone.

How is N-(2-Phenylethyl)acetamide (CAS: 877-95-2) typically synthesized?

N-(2-Phenylethyl)acetamide (CAS: 877-95-2) can be synthesized by reacting phenylethylamine with acetic anhydride in the presence of an acid catalyst like sulfuric acid. The yield is typically around 85%, and the reaction is exothermic. The product is purified by recrystallization from ethanol.

What industries use N-(2-Phenylethyl)acetamide (CAS: 877-95-2)?

N-(2-Phenylethyl)acetamide (CAS: 877-95-2) is primarily used in the pharmaceutical industry as a precursor for the synthesis of certain drugs. It is also used in the polymer industry as a stabilizer and in the sensor industry for its ability to interact with specific analytes.

What precautions should be taken when handling N-(2-Phenylethyl)acetamide (CAS: 877-95-2)?

When handling N-(2-Phenylethyl)acetamide (CAS: 877-95-2), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Storage should be in a cool, dry place away from direct sunlight. Fume hoods should be used during handling to minimize inhalation risk. Spills should be cleaned up carefully following standard safety procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information.