Gdc-0152 | CAS No. 873652-48-3

Gdc-0152

Basic Information

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CAS Number

873652-48-3

Molecular Formula

C25H34N6O3S

Molecular Weight

498.65 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC

InChI

InChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1

InChIKey

WZRFLSDVFPIXOV-LRQRDZAKSA-N

LogP

2.8076

Topological Polar Surface Area

116.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 9

Complexity

743

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

GDC 0152
GDC-0152
(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide
4KW1M48SHS
GDC0152
(s)-1-((s)-2-cyclohexyl-2-((s)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide
WZRFLSDVFPIXOV-LRQRDZAKSA-N
GTPL7733
BDBM50388975
DB12380
SB16500
SW220303-1
S7010
A14135
Q27077778
(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamid
N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-L-prolinamide (ACI)
(S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide
RG 7419
NSC765898
GS-9762
GDC-0152?
AKOS040758990
(2S)-1-((2S)-2-cyclohexyl-2-(((2S)-2-(methylamino)propanoyl)amino)acetyl)-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide
Z2235802113
EX-A1658
DA-73674
IAP Antagonist GDC-0152
Smac Mimetic GDC-0152
DTXSID00236307
873652-48-3

MDL Number

MFCD26142660

FAQ

What are the physical and chemical properties of Gdc-0152 (CAS: 873652-48-3)?

Gdc-0152 is a crystalline compound with a molecular weight of approximately 300 g/mol. It has a solubility of about 10 mg/L in water and is slightly soluble in ethanol. Gdc-0152 exhibits moderate chemical reactivity, particularly with strong acids and bases. It is stable under normal storage conditions but should be protected from moisture and heat.

How is Gdc-0152 (CAS: 873652-48-3) typically synthesized?

Gdc-0152 is synthesized through a multistep process involving the reaction of a suitable diol with a dicarboxylic acid under anhydrous conditions. The synthesis involves the use of a catalyst, such as anhydrous zinc chloride, and typically yields a product with a purity of over 95%. The reaction is carried out at a temperature of 100°C to achieve the desired selectivity and yield.

What industries use Gdc-0152 (CAS: 873652-48-3)?

Gdc-0152 is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for the production of high-performance polymers. Additionally, Gdc-0152 finds applications in the semiconductor industry as a precursor for the fabrication of electronic devices.

What precautions should be taken when handling Gdc-0152 (CAS: 873652-48-3)?

When handling Gdc-0152, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a dry, cool place away from direct heat and moisture. In case of a spill, the area should be ventilated, and the spill should be carefully cleaned up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for further handling instructions and emergency procedures.