Tetrahydro-2H-pyran-3-carboxylic acid

Basic Information

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CAS Number

873397-34-3

Molecular Formula

C6H10O3

Molecular Weight

130.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

264.5°C at 760 mmHg

Density

1.185

Flash Point

114℃

Refractive Index

1.472

SMILES

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C1CC(COC1)C(=O)O

InChI

InChI=1S/C6H10O3/c7-6(8)5-2-1-3-9-4-5/h5H,1-4H2,(H,7,8)

InChIKey

YEWPVCUHKJABMV-UHFFFAOYSA-N

LogP

0.49760000000000004

Topological Polar Surface Area

46.53 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

111

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2H-Pyran-3-carboxylicacid, tetrahydro-
oxane-3-carboxylic acid
CS-W001890
873397-34-3
Tetrahydro-2H-pyran-3-carboxylic acid, AldrichCPR
TETRAHYDRO-PYRAN-3-CARBOXYLIC ACID
EN300-44033
Z445214062
YEWPVCUHKJABMV-UHFFFAOYSA-N
SB45025
MFCD04114349
3-oxanecarboxylic acid
AC-29358
SY264892
SB45187
tetrahydro-2H-pyran-3-carboxylic?acid
tetrahydro-2H-pyran-3-carboxylic acid
(RS)-tetrahydro-pyran-3-carboxylic acid
FT-0601868
PB24847
Tetrahydro-2H-pyran-3-carboxylicacid
BCP07723
AM20110254
J-524878
A842097
SY020666
MFCD22681538
Tetrahydropyran-3-carboxylic acid
DS-15844
F0001-2175
2H-Pyran-3-carboxylicacid,tetrahydro-

MDL Number

MFCD04114349

Customs Code

2932999099

FAQ

What are the physical and chemical properties of Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3)?

Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3) is a colorless to white crystalline solid with a molecular weight of approximately 150.14 g/mol. It has a pKa of about 5.1 and is slightly soluble in water but soluble in common organic solvents like ethanol and acetonitrile. The compound is reactive, particularly in esterification and amidation reactions.

How is Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3) typically synthesized?

Tetrahydro-2H-pyran-3-carboxylic acid can be synthesized via a variety of routes, such as from 1,4-dioxane or 2-oxo-1,3-dioxolan-4-one. Common methods include acid catalyzed condensation reactions or direct oxidation of intermediate compounds, often employing catalysts like sulfuric acid or manganese dioxide. The yield is typically around 70-80%.

What industries use Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3)?

Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3) is used in pharmaceuticals for the synthesis of certain drug molecules, in polymers for incorporation into various plastic materials, and in the production of sensors and semiconductors due to its functional groups. It is also utilized in the development of functional materials and as a building block in organic synthesis.

What precautions should be taken when handling Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3)?

When handling Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3), wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation. Spills should be cleaned up with caution using appropriate absorbents. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.