Tetrahydro-2H-pyran-3-carboxylic acid(CAS: 873397-34-3)

Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3) is a colorless to white crystalline solid with a molecular weight of approximately 150.14 g/mol. It has a pKa of about 5.1 and is slightly soluble in water but soluble in common organic solvents like ethanol and acetonitrile. The compound is reactive, particularly in esterification and amidation reactions.

Tetrahydro-2H-pyran-3-carboxylic acid can be synthesized via a variety of routes, such as from 1,4-dioxane or 2-oxo-1,3-dioxolan-4-one. Common methods include acid catalyzed condensation reactions or direct oxidation of intermediate compounds, often employing catalysts like sulfuric acid or manganese dioxide. The yield is typically around 70-80%.

Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3) is used in pharmaceuticals for the synthesis of certain drug molecules, in polymers for incorporation into various plastic materials, and in the production of sensors and semiconductors due to its functional groups. It is also utilized in the development of functional materials and as a building block in organic synthesis.

When handling Tetrahydro-2H-pyran-3-carboxylic acid (CAS: 873397-34-3), wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation. Spills should be cleaned up with caution using appropriate absorbents. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.